Function Preservation

Function preservation in medicine refers to strategies that maintain the normal activity of an organ, tissue, or body system despite disease, injury, aging, or treatment. It works by identifying vulnerable functions, limiting damage, and supporting recovery through timely intervention, targeted therapy, rehabilitation, and continuous clinical monitoring. In surgical care, this principle can guide tissue-sparing procedures and protection of nerves, vessels, or organ performance; in chronic disease management, it supports treatments that slow functional decline. Preserving function can improve independence, quality of life, and long-term outcomes while informing preventive, restorative, and patient-centered care.

Function Preservation - Related Videos

Research

JoVE Journal - Medicine
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

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Cited by 29 •

2015

We describe a method of ex vivo machine perfusion of human liver grafts at subnormothermic temperature (21 °C).

Research

JoVE Journal - Immunology and Infection

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Cited by 17 •

2014

One key to successful investigation of microglial biology is the preservation of microglial immunofunction ex vivo during isolation from CNS tissue. Isolating microglia via rotary shaking results in highly pure and immunofunctional cell cultures as assessed by fluorescent imaging, immunocytochemistry, and ELISA following microglia activation with the proinflammatory stimuli lipopolysaccharide (LPS) and Pam3CSK4 (Pam).

Ex Situ Heart Perfusion: A Technique to Preserve Isolated Porcine Heart Function

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2025

This video describes an ex situ technique for preserving an isolated porcine heart by perfusing it with an oxygenated nutrient-rich perfusate solution. The technique allows the comprehensive evaluation of cardiac performance under physiological conditions.

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

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2025

Donor heart preservation is a major determinant of success in heart transplantation. Technological advances have led to optimizing the conditions of preservation, along with a more accurate assessment of the donor heart before transplantation. We herein describe two innovative technologies currently applied for cardiac preservation: uniform cooling preservation and normothermic ex-situ heart perfusion.

Education

JoVE Science Education - Basic Biology

Regulating Temperature in the Lab: Preserving Samples Using Cold

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2023

Preservation of laboratory samples, specimens, and reagents using extreme cold is routinely performed in biomedical research labs. This video will discuss some of the methods for keeping laboratory samples cold and will explain the correct cooling method to use for each experimental requirement. For example, cooling agents, such as ice and dry ice, are typically used when keeping samples cold during experiments. This video discusses the physical properties of the most commonly used cooling...

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