Intracardiac Pacing
Intracardiac Pacing - Related Videos
06:14
Translational Rabbit Model of Chronic Cardiac Pacing
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2023
We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies.
03:18
Stimulation of the Intracardiac Nervous System to Assess Susceptibility to Arrhythmia
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2025
Source: Jungen, C., et al. Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System. J. Vis. Exp. (2018).The video demonstrates an ex vivo technique for stimulating the intracardiac nervous system to assess the heart’s susceptibility to arrhythmia. Using a perfusion apparatus, an isolated mouse heart is perfused with an oxygenated buffer. The intracardiac nervous system is then stimulated at a high frequency to induce arrhythmias.
08:36
Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI
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Cited by 26 •
2014
A breast cancer brain metastasis mouse model is established with ultrasound imaging-guided intracardiac injection of MDA-MB231/Br-GFP cells. Development of multifocal intracranial metastases has been monitored longitudinally using high-resolution 9.4 T MRI.
04:38
Intracardiac Delivery of Viral Vectors: A Technique to Inject Viral Vectors Intracardially to Study Pancreatic Metastasis in Murine Model
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2023
This video describes the protocol for intracardiac injection of retroviruses into the transgenic mouse to ensure gene transfer into proliferating pancreatic β premalignant lesions. This method can also help in assessing the functions of candidate genes in tumor metastasis.
07:45
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
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Cited by 7 •
2017
Murine studies in models of colonic inflammation have demonstrated that a small percentage (1 - 5%) of mesenchymal stem cells (MSC) injected intravenously or intraperitoneally home to the inflamed colon1,2. This study shows that ultrasound-guided intracardiac injections of MSCs result in increased localization to the intestine.
FAQs
The electrode can detect existing cardiac activity and use that information to deliver stimuli at appropriate times. This interaction helps the pacing system respond to the heart’s rhythm rather than act independently of it. By aligning electrical input with cardiac activity, the approach supports more organized myocardial depolarization and helps maintain an adequate rate when native conduction is unreliable.
Depolarization is the electrical change that prompts cardiac muscle to contract. Intracardiac pacing uses a stimulus strong and appropriately timed enough to depolarize the myocardium, helping initiate contraction when the heart’s own conduction system does not provide dependable activation. The resulting electrical coordination is important because it supports effective, organized cardiac contraction rather than merely increasing the number of heartbeats.
The relationship between sensed cardiac activity and the intended pacing response determines how stimuli are timed. When the electrode detects cardiac activity, the system can respond to the existing rhythm; when dependable activity is absent or inadequate, timed stimulation can provide support. This distinction allows pacing to address unreliable conduction while limiting unnecessary electrical input when appropriate.
Experience with electrodes positioned inside the heart contributes to the development of leadless pacing systems. These systems are being explored as an option that may reduce complications associated with transvenous leads and broaden choices for selected patients. The connection is therefore both clinical and technological: intracardiac pacing provides a context for refining how electrical stimulation can be delivered without relying on conventional lead pathways.
A clinician positions an electrode within a cardiac chamber, establishes its ability to detect or respond to cardiac activity, and delivers electrical stimuli according to the required timing. The resulting myocardial response is then used to support cardiac rhythm and contraction. This workflow links electrode placement, rhythm interaction, and stimulation rather than treating electrical delivery as an isolated step.
Clinicians may use the technique when bradyarrhythmias require rhythm support or when temporary control is needed during a cardiac procedure. In these settings, pacing can help sustain an adequate heart rate while the immediate clinical problem or intervention is addressed. Its temporary role makes it useful when rhythm support is needed during a defined period rather than as a permanent strategy.
Its principal clinical roles include managing bradyarrhythmias, supporting rhythm during cardiac procedures, and assisting treatment of conduction disorders. The intended outcome is not simply electrical stimulation, but improved rhythm regulation that can support an adequate heart rate and coordinated contraction. The method is consequently relevant when impaired impulse generation or conduction compromises effective cardiac activity.