Portal Venous Flow

Portal venous flow is the movement of blood from the gastrointestinal tract, spleen, pancreas, and related organs to the liver, where absorbed substances undergo processing before entering systemic circulation. Blood travels through the portal vein and its branches into hepatic sinusoids, allowing hepatocytes to extract nutrients, metabolize drugs, and remove or transform potentially harmful compounds. In medicine, assessing portal venous flow helps evaluate liver circulation and detect abnormalities such as portal hypertension, thrombosis, or altered vascular resistance. Doppler ultrasound and other imaging methods can characterize flow direction and velocity, supporting diagnosis, treatment planning, and monitoring of chronic liver disease.

Portal Venous Flow - Related Videos

Research

JoVE Journal - Medicine

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

0 Views •

Cited by 5 •

2014

Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.

In Vivo Murine Liver Perfusion: A Method to Infuse the Rodent Liver with Solution via the Portal Vein

0 Views •

2023

This video describes a procedure for mouse liver perfusion through the portal vein using collagenase solution prior to isolating liver cells.

Portal Vein Injection: A Method to Study Cancer Metastasis to the Liver

0 Views •

2023

This video describes a surgical procedure to deliver mammary tumor cells to the murine liver via portal vein injection. This model permits the investigation of late stages of liver metastasis.

Research

JoVE Journal - Biology
Free Sample

Isolation of Rat Portal Fibroblasts by In situ Liver Perfusion

0 Views •

Cited by 22 •

2012

A technique for isolating portal fibroblasts from rat liver is described. Livers are perfused and digested in situ with collagenase, followed by ex vivo digestion of the liver slurry and size selection of cells. This method provides a pure population of portal fibroblasts without the need for passage in culture.

Education

JoVE Core - Pathophysiology

Portal Hypertension

0 Views •

2026

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...

View All Results

FAQs

Related Topics