Dorsal Laminectomy
Dorsal Laminectomy - Related Videos
06:39
Live Imaging of Dorsal Root Axons after Rhizotomy
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Cited by 6 •
2011
An in vivo imaging protocol to monitor primary sensory axons following dorsal root crush is described. The procedures utilize wide-field fluorescence microscopy and thy1-YFP transgenic mice, and permit repeated imaging of axon regeneration over 4 cm in the PNS and axon interactions with the interface of the CNS.
09:48
Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
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Cited by 9 •
2017
This protocol presents the use of a dorsal root ganglion (DRG) injection with a viral vector and a concurrent dorsal root crush injury in an adult rat as a model to study sensory axon regeneration. This model is suitable for investigating the use of gene therapy to promote sensory axon regeneration.
06:59
Laminectomy and Spinal Cord Window Implantation in the Mouse
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2019
This protocol describes implantation of a glass window onto the spinal cord of a mouse to facilitate visualization by intravital microscopy.
06:56
Isolation of Macrophages from Mouse Dorsal Root Ganglion Using Mechanical Dissociation
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2025
This video demonstrates an enzyme-free protocol to isolate macrophages from mouse dorsal root ganglion (DRG) using a mechanical dissociation technique. Upon homogenization of the freshly collected DRG tissue, antibodies against the cell-surface receptors on the macrophages are used to label the cells fluorescently, followed by performing flow cytometry to confirm the presence of macrophages in the sample.
09:41
Chromatin Immunoprecipitation from Dorsal Root Ganglia Tissue following Axonal Injury
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Cited by 9 •
2011
We present a method for chromatin immunoprecipitation from dorsal root ganglia tissue following axonal injury. The approach can be used to identify specific transcription factor binding sites and epigenetic modification of histone and DNA important for the regeneration of injured axons in both the peripheral and central nervous system.
FAQs
Removing part or all of the lamina enlarges the spinal canal, creating additional space around the spinal cord and nerve roots. This change can relieve pressure caused by compressive tissue, tumors, or other lesions. The resulting neural decompression depends on whether the opening provides sufficient space to address the specific source and location of compression.
The extent of bone removal influences both access to affected neural structures and preservation of spinal stability. A partial removal may provide access or decompression while retaining more of the vertebral arch, whereas complete removal creates a larger opening. The appropriate extent therefore depends on the underlying condition, the required decompression, and the need to maintain stability.
The opening created in the vertebral arch can expose the region containing affected neural structures and permit removal of compressive tissue, tumors, or other lesions. This makes the procedure useful not only for enlarging the canal, but also for obtaining surgical access to the source of compression and addressing it directly when appropriate.
Outcomes depend primarily on the underlying condition, how extensively the spinal canal is decompressed, and whether spinal stability is preserved. Decompression must address the relevant source of pressure, while the amount of bone removed affects the structural state of the vertebral arch. These factors help determine the procedure’s effectiveness for a particular spinal problem.
The central operative sequence is to remove part or all of the lamina, create an opening in the vertebral arch, and use the resulting access to relieve pressure or address an associated lesion. The procedure’s specific scope varies with the underlying condition and the extent of decompression required, rather than following one identical pattern for every case.
In neuroscience, dorsal laminectomy provides access to the spinal cord for experimental procedures as well as for treatment of spinal cord compression. Its value in research comes from opening the posterior vertebral arch so investigators can work with spinal neural structures. The approach therefore connects clinical management of compression with experimental study of the spinal cord.