Physiological Stress

Physiological stress is the body’s coordinated response to perceived or actual challenges, helping maintain stability when demands disrupt normal conditions. In psychology, stress activates the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, prompting the release of adrenaline and cortisol; these responses increase alertness, cardiovascular activity, and energy availability, while recovery systems restore baseline function after the threat passes. Acute stress can support attention and adaptive behavior, whereas persistent or poorly regulated activation may affect sleep, mood, cognition, and physical health. Studying physiological stress helps researchers evaluate stress-related disorders, understand mind-body interactions, and assess the effects of coping strategies and clinical interventions.

Physiological Stress - Related Videos

Education

JoVE Core - Introduction to Psychology

Physiological Foundation of Stress

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2025

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands. Role of the Sympathetic Nervous System Adrenaline triggers the...

Research

JoVE Journal - Biology

Measurements of Physiological Stress Responses in C. Elegans

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Cited by 44 •

2020

Here, we characterize cellular proteotoxic stress responses in the nematode C. elegans by measuring the activation of fluorescent transcriptional reporters and assaying sensitivity to physiological stress.

Research

JoVE Journal - Biology
Free Sample

Linking Predation Risk, Herbivore Physiological Stress and Microbial Decomposition of Plant Litter

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Cited by 6 •

2013

We present methods to evaluate how predation risk can alter the chemical quality of herbivore prey by inducing dietary changes to meet demands of heightened stress, and how the decomposition of carcasses from these stressed herbivores slows subsequent plant litter decomposition by soil microbes.

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

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Cited by 25 •

2015

Here, methods for developing a mouse model of subchronic and mild social defeat stress are described and used to investigate the pathogenic features of depression including hyperphagia- and polydipsia-like symptoms following increased body weight.

A Community-based Stress Management Program: Using Wearable Devices to Assess Whole Body Physiological Responses in Non-laboratory Settings

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Cited by 1 •

2018

Stress is an unavoidable and persistent component of life and holistic approaches for its management are being considered. A standardized methodology was created to demonstrate the feasibility of a breath-based stress management protocol that can be used with commercially available portable technology.

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