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November 29, 2013
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Protein conformation and dynamics are key to understanding the relationship between protein structure and function. Hydrogen exchange coupled with high-resolution mass spectrometry is a versatile method to study the conformational dynamics of proteins as well as characterizing protein-ligand and protein-protein interactions, including contact interfaces and allosteric effects.
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Hentze, N., Mayer, M. P. Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry. J. Vis. Exp. (81), e50839, doi:10.3791/50839 (2013).
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