The metastatic spread of cancer is the major cause of cancer-related deaths. We provide an in-depth description of our survival surgery methodology for establishing a “patient-like” orthotopic syngeneic mouse model system for studying the mechanisms of metastasis in solid organ tumors.
Das, D. K., Durojaiye, V., Ilboudo, A., Naidoo, M. K., Ogunwobi, O. A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis. J. Vis. Exp. (104), e52858, doi:10.3791/52858 (2015).