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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
JoVE Journal
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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

English

Automatycznie wygenerowane
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11,885 Views

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05:49 min

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October 13, 2018

DOI:

10.3791/58306-v

DOI:
10.3791/58306-v

•

05:49 min
October 13, 2018

•

10 Views
, ,
1Department of Psychology,University of California, Los Angeles, 2Staglin Center for Brain and Behavioral Health,University of California, Los Angeles, 3Department of Psychiatry and Biobehavioral Sciences,University of California, Los Angeles

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Here we describe the detailed methodology required to conduct stress-enhanced fear learning (SEFL) experiments, a preclinical model of post-traumatic stress disorder, in both rats and mice. The model utilizes aspects of Pavlovian fear conditioning and freezing as an index of enhanced fear in rodents.

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Rajbhandari, A. K., Gonzalez, S. T., Fanselow, M. S. Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder. J. Vis. Exp. (140), e58306, doi:10.3791/58306 (2018).

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