A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

Nicholas  E. Buglak; Edward S. M. Bahnson

doi:10.3791/60473

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A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

JoVE Journal
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JoVE Journal Medycyna

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

4,902 Views

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06:53 min

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July 09, 2020

DOI:

10.3791/60473-v

DOI:

10.3791/60473-v

•

06:53 min

July 09, 2020

•

6 Views

Nicholas E. Buglak^1,2,3,5, Edward S. M. Bahnson^1,2,3,4,5

¹Department of Surgery, Division of Vascular Surgery,University of North Carolina at Chapel Hill, ²Center for Nanotechnology in Drug Delivery,University of North Carolina at Chapel Hill, ³Curriculum in Toxicology & Environmental Medicine,University of North Carolina at Chapel Hill, ⁴Department of Cell Biology & Physiology,University of North Carolina at Chapel Hill, ⁵McAllister Heart Institute,University of North Carolina at Chapel Hill

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Podsumowanie

The rat carotid artery balloon injury mimics the clinical angioplasty procedure performed to restore blood flow in atherosclerotic vessels. This model induces the arterial injury response by distending the arterial wall, and denuding the intimal layer of endothelial cells, ultimately causing remodeling and an intimal hyperplastic response.