Dissection of the Endolymphatic Sac from Mice

Keiji Honda; Hyun Jae Lee; Andrew J. Griffith; Isabelle Roux

doi:10.3791/62375

Dziennik

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Biologia

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Dissection of the Endolymphatic Sac from Mice

JoVE Journal
Biologia

This content is Free Access.

JoVE Journal Biologia

Dissection of the Endolymphatic Sac from Mice

2,063 Views

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04:34 min

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March 29, 2021

DOI:

10.3791/62375-v

DOI:

10.3791/62375-v

•

04:34 min

March 29, 2021

•

18 Views

Keiji Honda*^1,2, Hyun Jae Lee*¹, Andrew J. Griffith^1,3, Isabelle Roux¹

¹Otolaryngology Branch,National Institute on Deafness and Other Communication Disorders, National Institutes of Health, ²Department of Otorhinolaryngology,Tokyo Medical and Dental University, ³Department of Otolaryngology,College of Medicine, University of Tennessee Health Science Center

Transkrypcja

Podsumowanie

This study describes how to dissect the endolymphatic sac from the inner ear of the mouse at different ages. The result of a similar dissection is shown in an Slc26a4-null mouse model of enlargement of the endolymphatic sac. A transgenic mouse with a fluorescent reporter expressed in the endolymphatic sac is presented as a model to readily visualize the endolymphatic sac, and educational tool.