Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Fr&#233;d&#233;rique Lisacek

doi:10.3791/63356

Zasoby bioinformatyczne do badania oddziaływań białek za pośrednictwem glikanów

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Biology

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JoVE Journal Biology

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Zasoby bioinformatyczne do badania oddziaływań białek za pośrednictwem glikanów

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11:21 min

January 20, 2022

DOI: 10.3791/63356-v

Frédérique Lisacek^1,2,3

¹Proteome Informatics Group,SIB Swiss Institute of Bioinformatics, ²Computer Science Department,University of Geneva, ³Section of Biology,University of Geneva

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Overview

This protocol illustrates the use of glycoinformatics to explore and interpret human protein glycomes using various online resources. The integration of databases facilitates the visualization and comparison of glycomic data to gain insights into the role of glycans in health and disease.

Key Study Components

Research Area

Glycoinformatics
Human protein glycomes
Health and disease relevance of glycans

Background

Importance of glycans in biology
Development of databases for glycomics/glycoproteomics
Role of technology in advancing glyco biology

Methods Used

Bioinformatic tools and databases
Online resources for visualizing glycomic data
Comparative analysis methods

Main Results

Insights into glycan structures associated with proteins
Data supporting connections between glycosylation and disease states
Tools demonstrated to enhance understanding of glyco biology

Conclusions

Glycoinformatics tools are essential for exploring human glycomes.
This approach facilitates breakthroughs in understanding glycans’ biological roles.

Frequently Asked Questions

What is glycoinformatics?

Glycoinformatics is the application of computational methods to analyze and interpret glycomics data.

Why are glycans important?

Glycans play critical roles in various biological processes and are significant in health and disease mechanisms.

What types of databases are used in glycoinformatics?

Databases that store glycomics and glycoproteomics data are commonly used for browsing and searching.

How can glycoinformatics aid in disease research?

It provides insights into glycan structures that may be linked to diseases, aiding in diagnostics and therapeutics.

What tools are available for visualizing glycomic data?

Several online tools exist that allow users to visualize and compare glycomic data effectively.

What are some applications of glycoinformatics?

Applications include research in health and disease correlations, and the development of therapeutic strategies.

Ten protokół ilustruje, jak badać, porównywać i interpretować ludzkie glicomes białkowe za pomocą zasobów online.

Bioinformatyka polega na używaniu komputerów do rozwiązywania problemów z biologii. Glikoinformatyka polega na używaniu komputerów do rozwiązywania problemów z zakresu biologii gliko. Dzięki glycoinformatics tworzymy bazy danych, które przechowują dane glikomiczne lub glikoproteomiczne, które można przeglądać lub przeszukiwać, a także opracowujemy narzędzia do wizualizacji i porównywania tych danych.

Rola glikanów jest coraz częściej uznawana za ważną w zdrowiu i chorobie, a glikoinformatyka stara się również to promować. Catherine Hayes jest z wykształcenia biologia glikologiczna i pracuje jako naukowiec zajmujący się danymi. Julien Mariethoz jest z wykształcenia informatykiem i koordynuje rozwój baz danych i narzędzi.

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