Hermona Soreq Department of Biological Chemistry and The Edmond & Lily Safra Center for Brain Sciences The Hebrew University of Jerusalem Biography Publications Institution JoVE Articles Hermona Soreq has not added a biography. If you are Hermona Soreq and would like to personalize this page please email our Author Liaison for assistance. Publications Small RNA Sequencing-microarray Analyses in Parkinson Leukocytes Reveal Deep Brain Stimulation-induced Splicing Changes That Classify Brain Region Transcriptomes Frontiers in Molecular Neuroscience. 2013 | Pubmed ID: 23717260 MicroRNA-132 Modulates Cholinergic Signaling and Inflammation in Human Inflammatory Bowel Disease Inflammatory Bowel Diseases. Jun, 2013 | Pubmed ID: 23598815 Statistically Invalid Classification of High Throughput Gene Expression Data Scientific Reports. 2013 | Pubmed ID: 23346359 Plasma Acetylcholinesterase Activity Correlates with Intracerebral β-amyloid Load Current Alzheimer Research. Jan, 2013 | Pubmed ID: 23157337 Acetylcholinesterase: Old Questions and New Developments Frontiers in Molecular Neuroscience. 2012 | Pubmed ID: 23316131 Further Developments with Antisense Treatment for Myasthenia Gravis Annals of the New York Academy of Sciences. Dec, 2012 | Pubmed ID: 23278572 Heterogeneous Nuclear Ribonucleoprotein A1 in Health and Neurodegenerative Disease: From Structural Insights to Post-transcriptional Regulatory Roles Molecular and Cellular Neurosciences. Dec, 2012 | Pubmed ID: 23247072 Stress-induced Epigenetic Transcriptional Memory of Acetylcholinesterase by HDAC4 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23236169 Blood-brain Barrier Dysfunction-induced Inflammatory Signaling in Brain Pathology and Epileptogenesis Epilepsia. Nov, 2012 | Pubmed ID: 23134494 Fluoxetine Induces Vasodilatation of Cerebral Arterioles by Co-modulating NO/muscarinic Signalling Journal of Cellular and Molecular Medicine. Nov, 2012 | Pubmed ID: 22697296 Acetylcholinesterase Loosens the Brain's Cholinergic Anti-inflammatory Response and Promotes Epileptogenesis Frontiers in Molecular Neuroscience. 2012 | Pubmed ID: 22639569 Cholinergic-associated Loss of HnRNP-A/B in Alzheimer's Disease Impairs Cortical Splicing and Cognitive Function in Mice EMBO Molecular Medicine. Aug, 2012 | Pubmed ID: 22628224 Stressing Hematopoiesis and Immunity: an Acetylcholinesterase Window into Nervous and Immune System Interactions Frontiers in Molecular Neuroscience. 2012 | Pubmed ID: 22448158 Meta-analysis of Genetic and Environmental Parkinson's Disease Models Reveals a Common Role of Mitochondrial Protection Pathways Neurobiology of Disease. Mar, 2012 | Pubmed ID: 22198569 Threshold-independent Meta-analysis of Alzheimer's Disease Transcriptomes Shows Progressive Changes in Hippocampal Functions, Epigenetics and MicroRNA Regulation Current Alzheimer Research. May, 2012 | Pubmed ID: 22191566 Exon Arrays Reveal Alternative Splicing Aberrations in Parkinson's Disease Leukocytes Neuro-degenerative Diseases. 2012 | Pubmed ID: 22156489 Nicotinic Stimulation Induces Tristetraprolin Over-production and Attenuates Inflammation in Muscle Biochimica Et Biophysica Acta. Feb, 2012 | Pubmed ID: 22093924 Predictors for Poststroke Outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) Study Protocol International Journal of Stroke : Official Journal of the International Stroke Society. Jun, 2012 | Pubmed ID: 22044517 Adaptive Alternative Splicing Correlates with Less Environmental Risk of Parkinsonism Neuro-degenerative Diseases. 2012 | Pubmed ID: 22042332 Deep Brain Stimulation Induces Rapidly Reversible Transcript Changes in Parkinson's Leucocytes Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 21910823 Similar Cation Channels Mediate Protection from Cerebellar Exitotoxicity by Exercise and Inheritance Journal of Cellular and Molecular Medicine. Mar, 2012 | Pubmed ID: 21507200 Quantum Dot Labeling of Butyrylcholinesterase Maintains Substrate and Inhibitor Interactions and Cell Adherence Features ACS Chemical Neuroscience. Mar, 2011 | Pubmed ID: 22778863 Activation of the Alternative NFκB Pathway Improves Disease Symptoms in a Model of Sjogren's Syndrome PloS One. 2011 | Pubmed ID: 22174879 Cholinesterase-Targeting MicroRNAs Identified in Silico Affect Specific Biological Processes Frontiers in Molecular Neuroscience. 2011 | Pubmed ID: 22007158 Letter by Shenhar-Tsarfaty Et Al Regarding Article, "Autonomic Shift and Increased Susceptibility to Infections After Acute Intracerebral Hemorrhage" Stroke; a Journal of Cerebral Circulation. Oct, 2011 | Pubmed ID: 21868734 NeurimmiRs: MicroRNAs in the Neuroimmune Interface Trends in Molecular Medicine. Oct, 2011 | Pubmed ID: 21813326 Effects of Physostigmine on Microcirculatory Alterations During Experimental Endotoxemia Shock (Augusta, Ga.). May, 2011 | Pubmed ID: 21499071 Cholinesterase Modulations in Patients with Acute Bacterial Meningitis Scandinavian Journal of Clinical and Laboratory Investigation. Jul, 2011 | Pubmed ID: 21303225 Butyrylcholinesterase Interactions with Amylin May Protect Pancreatic Cells in Metabolic Syndrome Journal of Cellular and Molecular Medicine. Aug, 2011 | Pubmed ID: 20807286 Plant-derived Human Butyrylcholinesterase, but Not an Organophosphorous-compound Hydrolyzing Variant Thereof, Protects Rodents Against Nerve Agents Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21059932 Engineering DYRK1A Overdosage Yields Down Syndrome-characteristic Cortical Splicing Aberrations Neurobiology of Disease. Oct, 2010 | Pubmed ID: 20600907 Serum Cholinesterase Activities Distinguish Between Stroke Patients and Controls and Predict 12-month Mortality Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2010 | Pubmed ID: 20464061 Transgenic Plants As a Source for the Bioscavenging Enzyme, Human Butyrylcholinesterase Plant Biotechnology Journal. Oct, 2010 | Pubmed ID: 20353404 Acetylcholinesterase Variants in Alzheimer's Disease: from Neuroprotection to Programmed Cell Death Neuro-degenerative Diseases. 2010 | Pubmed ID: 20173328 Alanine-to-threonine Substitutions and Amyloid Diseases: Butyrylcholinesterase As a Case Study Chemico-biological Interactions. Sep, 2010 | Pubmed ID: 20060816 Erythropoietin Attenuates Hyperoxia-induced Oxidative Stress in the Developing Rat Brain Brain, Behavior, and Immunity. Jul, 2010 | Pubmed ID: 19729061 Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions Journal of Molecular Neuroscience : MN. Jan, 2010 | Pubmed ID: 19711202 MicroRNA-132 Potentiates Cholinergic Anti-inflammatory Signaling by Targeting Acetylcholinesterase Immunity. Dec, 2009 | Pubmed ID: 20005135 Pro-apoptotic Protein-protein Interactions of the Extended N-AChE Terminus Journal of Neural Transmission (Vienna, Austria : 1996). Nov, 2009 | Pubmed ID: 19533292 The Butyrylcholinesterase K Variant Confers Structurally Derived Risks for Alzheimer Pathology The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19383604 Heterogeneous Nuclear Ribonucleoprotein G Regulates Splice Site Selection by Binding to CC(A/C)-rich Regions in Pre-mRNA The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19282290 A Network-based Method for Predicting Disease-causing Genes Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. Feb, 2009 | Pubmed ID: 19193144 Stress-induced Alternative Splicing Modulations in Brain and Periphery: Acetylcholinesterase As a Case Study Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120119 N-acetylcholinesterase-induced Apoptosis in Alzheimer's Disease PloS One. 2008 | Pubmed ID: 18769671 Advanced Microarray Analysis Highlights Modified Neuro-immune Signaling in Nucleated Blood Cells from Parkinson's Disease Patients Journal of Neuroimmunology. Sep, 2008 | Pubmed ID: 18692253 Alternate AChE-R Variants Facilitate Cellular Metabolic Activity and Resistance to Genotoxic Stress Through Enolase and RACK1 Interactions Chemico-biological Interactions. Sep, 2008 | Pubmed ID: 18572152 Antisense Treatment for Myasthenia Gravis: Experience with Monarsen Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567879 Identifying Alternative Hyper-splicing Signatures in MG-thymoma by Exon Arrays PloS One. 2008 | Pubmed ID: 18545673 The Structural Basis of Amyloid Formation Current Alzheimer Research. Jun, 2008 | Pubmed ID: 18537539 Acetylcholine-induced Seizure-like Activity and Modified Cholinergic Gene Expression in Chronically Epileptic Rats The European Journal of Neuroscience. Feb, 2008 | Pubmed ID: 18333967 The Role of the Read Through Variant of Acetylcholinesterase in Anxiogenic Effects of Predator Stress in Mice Behavioural Brain Research. May, 2008 | Pubmed ID: 18243359 Introduction: Cholinesterases, from Molecular Complexity to Non-hydrolytic Functions The FEBS Journal. Feb, 2008 | Pubmed ID: 18205835 Changes in Readthrough Acetylcholinesterase Expression Modulate Amyloid-beta Pathology Brain : a Journal of Neurology. Jan, 2008 | Pubmed ID: 18056160 Cytokines and Cholinergic Signals Co-modulate Surgical Stress-induced Changes in Mood and Memory Brain, Behavior, and Immunity. Mar, 2008 | Pubmed ID: 17959355 Acetylcholinesterase Activity in Veterans of the First Gulf War Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research. Nov, 2007 | Pubmed ID: 18062897 Cholinergic Status Modulations in Human Volunteers Under Acute Inflammation Journal of Molecular Medicine (Berlin, Germany). Nov, 2007 | Pubmed ID: 17657467 Peripheral Site Acetylcholinesterase Blockade Induces RACK1-associated Neuronal Remodeling Neuro-degenerative Diseases. 2007 | Pubmed ID: 17596712 Translational Control of Recombinant Human Acetylcholinesterase Accumulation in Plants BMC Biotechnology. 2007 | Pubmed ID: 17537261 Plant-derived Human Acetylcholinesterase-R Provides Protection from Lethal Organophosphate Poisoning and Its Chronic Aftermath FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2007 | Pubmed ID: 17475919 Readthrough Acetylcholinesterase in Inflammation-associated Neuropathies Life Sciences. May, 2007 | Pubmed ID: 17379257 A Novel Isoform of Acetylcholinesterase Exacerbates Photoreceptors Death After Photic Stress Investigative Ophthalmology & Visual Science. Mar, 2007 | Pubmed ID: 17325175 The Thymic Theme of Acetylcholinesterase Splice Variants in Myasthenia Gravis Blood. May, 2007 | Pubmed ID: 17272501 It is All About Resolution. Meeting Report Based Upon Presentations at the 10th International Global BioMillennium 2006 Symposium on Molecular Cell Biology (Tbilisi, Georgia) The FEBS Journal. Feb, 2007 | Pubmed ID: 17269934 Impaired Hippocampal Plasticity and Errors in Cognitive Performance in Mice with Maladaptive AChE Splice Site Selection The European Journal of Neuroscience. Jan, 2007 | Pubmed ID: 17241270 Adaptive Changes in Acetylcholinesterase Gene Expression As Mediators of Recovery from Chemical and Biological Insults Toxicology. Apr, 2007 | Pubmed ID: 17005312 Readthrough Acetylcholinesterase: a Multifaceted Inducer of Stress Reactions Journal of Molecular Neuroscience : MN. 2006 | Pubmed ID: 17192675 Neuromuscular Therapeutics by RNA-targeted Suppression of ACHE Gene Expression Annals of the New York Academy of Sciences. Oct, 2006 | Pubmed ID: 17145929 Acetylcholinesterase Modulates Stress-induced Motor Responses Through Catalytic and Noncatalytic Properties Biological Psychiatry. Oct, 2006 | Pubmed ID: 16904653 Coding Region Paraoxonase Polymorphisms Dictate Accentuated Neuronal Reactions in Chronic, Sub-threshold Pesticide Exposure FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006 | Pubmed ID: 16807370 Gene-environment Interactions in Sporadic Parkinson's Disease Journal of Neurochemistry. Jun, 2006 | Pubmed ID: 16805780 Termination and Beyond: Acetylcholinesterase As a Modulator of Synaptic Transmission Cell and Tissue Research. Nov, 2006 | Pubmed ID: 16802134 Butyrylcholinesterase Attenuates Amyloid Fibril Formation in Vitro Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16731619 ARP, the Cleavable C-terminal Peptide of "readthrough" Acetylcholinesterase, Promotes Neuronal Development and Plasticity Journal of Molecular Neuroscience : MN. 2006 | Pubmed ID: 16691012 Modulated Splicing-associated Gene Expression in P19 Cells Expressing Distinct Acetylcholinesterase Splice Variants Journal of Neurochemistry. Apr, 2006 | Pubmed ID: 16635247 Tugenden Und Leiden Der AChE Alternatives Spleißen in Betonen-in Verbindung Stehende Neuropathologies Trends in Neurosciences. Apr, 2006 | Pubmed ID: 16516310 RACK1 Has the Nerve to Act: Structure Meets Function in the Nervous System Progress in Neurobiology. Feb, 2006 | Pubmed ID: 16457939 Stress-induced Cholinergic Signaling Promotes Inflammation-associated Thrombopoiesis Blood. Apr, 2006 | Pubmed ID: 16380450 Hydrolytic and Nonenzymatic Functions of Acetylcholinesterase Comodulate Hemopoietic Stress Responses Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16365392 MicroRNA Modulation of Megakaryoblast Fate Involves Cholinergic Signaling Leukemia Research. May, 2006 | Pubmed ID: 16249029 RNA-targeted Suppression of Stress-induced Allostasis in Primate Spinal Cord Neurons Neuro-degenerative Diseases. 2005 | Pubmed ID: 16908999 Characterizing Pea Acetylcholinesterase Chemico-biological Interactions. Dec, 2005 | Pubmed ID: 16429548 Purification of Transgenic Plant-derived Recombinant Human Acetylcholinesterase-R Chemico-biological Interactions. Dec, 2005 | Pubmed ID: 16269140 Cellular Stress Reactions As Putative Cholinergic Links in Alzheimer's Disease Neurochemical Research. Jun-Jul, 2005 | Pubmed ID: 16187225 Memory Deficits Correlating with Acetylcholinesterase Splice Shift and Amyloid Burden in Doubly Transgenic Mice Current Alzheimer Research. Jul, 2005 | Pubmed ID: 15974894 Chronische Cholinergen Ungleichgewichte Zu Fördern Gehirn Diffusion Und Transport Anomalien FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005 | Pubmed ID: 15923401 Acetylcholinesterase Inhibitors Reduce Brain and Blood Interleukin-1beta Production Annals of Neurology. May, 2005 | Pubmed ID: 15852394 Functional Manipulations of Acetylcholinesterase Splice Variants Highlight Alternative Splicing Contributions to Murine Neocortical Development Cerebral Cortex (New York, N.Y. : 1991). Apr, 2005 | Pubmed ID: 15749986 Inherited and Acquired Interactions Between ACHE and PON1 Polymorphisms Modulate Plasma Acetylcholinesterase and Paraoxonase Activities Journal of Neurochemistry. Mar, 2005 | Pubmed ID: 15715671 Function of Alternative Splicing Gene. Jan, 2005 | Pubmed ID: 15656968 Acetylcholinesterase/paraoxonase Interactions Increase the Risk of Insecticide-induced Parkinson's Disease FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2005 | Pubmed ID: 15629887 Identifying Subtle Interrelated Changes in Functional Gene Categories Using Continuous Measures of Gene Expression Bioinformatics (Oxford, England). Apr, 2005 | Pubmed ID: 15550480 Tissue Distribution of Cholinesterases and Anticholinesterases in Native and Transgenic Tomato Plants Plant Molecular Biology. May, 2004 | Pubmed ID: 15604663 Excessive Expression of Acetylcholinesterase Impairs Glutamatergic Synaptogenesis in Hippocampal Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15483114 Blood-cell-specific Acetylcholinesterase Splice Variations Under Changing Stimuli International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. Nov, 2004 | Pubmed ID: 15465282 From Brain to Blood: Alternative Splicing Evidence for the Cholinergic Basis of Mammalian Stress Responses Annals of the New York Academy of Sciences. Jun, 2004 | Pubmed ID: 15240356 Organophosphate Risk of Leukemogenesis Leukemia Research. Sep, 2004 | Pubmed ID: 15234565 CREB Regulates AChE-R-induced Proliferation of Human Glioblastoma Cells Neoplasia (New York, N.Y.). May-Jun, 2004 | Pubmed ID: 15153340 Kombinatorische Komplexität Der 5 'Alternative Acetylcholinesterase-Transkripte Und Protein-Produkte The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15123727 Acetylcholinesterase/paraoxonase Genotype and Expression Predict Anxiety Scores in Health, Risk Factors, Exercise Training, and Genetics Study Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15060281 Endotoxin-induced Changes in Human Working and Declarative Memory Associate with Cleavage of Plasma "readthrough" Acetylcholinesterase Journal of Molecular Neuroscience : MN. 2003 | Pubmed ID: 14645987 Ethics, Public Policy and Behavioral Genetics The Israel Medical Association Journal : IMAJ. Feb, 2003 | Pubmed ID: 12674653 The Role of Readthrough Acetylcholinesterase in the Pathophysiology of Myasthenia Gravis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2003 | Pubmed ID: 12554700 Interaction of "readthrough" Acetylcholinesterase with RACK1 and PKCbeta II Correlates with Intensified Fear-induced Conflict Behavior Proceedings of the National Academy of Sciences of the United States of America. Jan, 2003 | Pubmed ID: 12509514 Chronic Acetylcholinesterase Overexpression Induces Multilevelled Aberrations in Mouse Neuromuscular Physiology The Journal of Physiology. Jan, 2003 | Pubmed ID: 12509486 Pre-mRNA-Spleißen Modulationen in Seneszenz Aging Cell. Oct, 2002 | Pubmed ID: 12882348 Defekte Im Pre-mRNA Verarbeitung Als Ursachen Und Prädisposition Für Krankheiten DNA and Cell Biology. Nov, 2002 | Pubmed ID: 12489991 Complex Regulation of Acetylcholinesterase Gene Expression in Human Brain Tumors Oncogene. Dec, 2002 | Pubmed ID: 12466963 The Stress-associated Acetylcholinesterase Variant AChE-R is Expressed in Human CD34(+) Hematopoietic Progenitors and Its C-terminal Peptide ARP Promotes Their Proliferation Experimental Hematology. Oct, 2002 | Pubmed ID: 12384146 Transcriptional Regulation of Erythropoiesis. Fine Tuning of Combinatorial Multi-domain Elements European Journal of Biochemistry / FEBS. Aug, 2002 | Pubmed ID: 12153557 Upregulation of Neuronal Nicotinic Receptor Subunits Alpha4, Beta2, and Alpha7 in Transgenic Mice Overexpressing Human Acetylcholinesterase Journal of Molecular Neuroscience : MN. Jun, 2002 | Pubmed ID: 12059039 Alternatives Spleißen Und Neuritischen MRNA-Translokation Im Rahmen Langfristiger Neuronale Überempfindlichkeit Science (New York, N.Y.). Jan, 2002 | Pubmed ID: 11799248 Runx1/AML1 in Leukemia: Disrupted Association with Diverse Protein Partners Leukemia Research. Mar, 2002 | Pubmed ID: 11792409 Stereotaktische Injektion von microRNA-exprimierenden Lentiviren der Maus Hippocampus CA1 Region und Beurteilung der Behavioral Outcome Shahar Barbash1, Geula Hanin1, Hermona Soreq1 1Department of Biological Chemistry and The Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem JoVE 50170 Comportamento
Stereotaktische Injektion von microRNA-exprimierenden Lentiviren der Maus Hippocampus CA1 Region und Beurteilung der Behavioral Outcome Shahar Barbash1, Geula Hanin1, Hermona Soreq1 1Department of Biological Chemistry and The Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem JoVE 50170 Comportamento