Melanie H. Cobb Department of Pharmacology University of Texas Southwestern Medical Center Biography Publications Institution JoVE Articles Melanie H. Cobb has not added a biography. If you are Melanie H. Cobb and would like to personalize this page please email our Author Liaison for assistance. Publications WNK Pathways in Cancer Signaling Networks Cell Communication and Signaling : CCS. 11, 2018 | Pubmed ID: 30390653 Chromomycin A Potently Inhibits Glucose-stimulated Insulin Secretion from Pancreatic β Cells The Journal of General Physiology. Dec, 2018 | Pubmed ID: 30352794 Pulling a MAST1 on Cisplatin Resistance Cancer Cell. 08, 2018 | Pubmed ID: 30107173 OSR1 Regulates a Subset of Inward Rectifier Potassium Channels Via a Binding Motif Variant Proceedings of the National Academy of Sciences of the United States of America. 04, 2018 | Pubmed ID: 29581290 Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization Developmental Cell. 03, 2018 | Pubmed ID: 29503158 The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors Translational Oncology. Apr, 2018 | Pubmed ID: 29413762 Differential Abundance of CK1α Provides Selectivity for Pharmacological CK1α Activators to Target WNT-dependent Tumors Science Signaling. Jun, 2017 | Pubmed ID: 28655862 Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell Pharmacology & Therapeutics. Nov, 2017 | Pubmed ID: 28527919 WNK1 is an Unexpected Autophagy Inhibitor Autophagy. Feb, 2017 | Pubmed ID: 28282258 Sucralose Activates an ERK1/2-ribosomal Protein S6 Signaling Axis FEBS Open Bio. Feb, 2017 | Pubmed ID: 28174684 Chemoattractant Concentration-dependent Tuning of ERK Signaling Dynamics in Migrating Neutrophils Science Signaling. Dec, 2016 | Pubmed ID: 27965424 Multistep Regulation of Autophagy by WNK1 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2016 | Pubmed ID: 27911840 Insulin Promoter-driven Gaussia Luciferase-based Insulin Secretion Biosensor Assay for Discovery of β-cell Glucose-sensing Pathways ACS Sensors. Oct, 2016 | Pubmed ID: 27819058 Amino Acids Regulate MTORC1 by an Obligate Two-step Mechanism The Journal of Biological Chemistry. Oct, 2016 | Pubmed ID: 27587390 Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis Via Nonmuscle Myosin II Circulation Research. Sep, 2016 | Pubmed ID: 27486147 ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs Cell Reports. Aug, 2016 | Pubmed ID: 27452466 Hypertension: the Missing WNKs American Journal of Physiology. Renal Physiology. Jul, 2016 | Pubmed ID: 27009339 Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding Biochemistry. Mar, 2016 | Pubmed ID: 26950759 Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Apr, 2016 | Pubmed ID: 26829312 Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells ACS Chemical Biology. Apr, 2016 | Pubmed ID: 26828310 A Kinase Divided Cancer Cell. Aug, 2015 | Pubmed ID: 26267529 Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK Biochemistry. Aug, 2015 | Pubmed ID: 26208601 Differential Regulation of ERK1/2 and MTORC1 Through T1R1/T1R3 in MIN6 Cells Molecular Endocrinology (Baltimore, Md.). Aug, 2015 | Pubmed ID: 26168033 Actions of the Protein Kinase WNK1 on Endothelial Cells Are Differentially Mediated by Its Substrate Kinases OSR1 and SPAK Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25362046 ASCL1 is a Lineage Oncogene Providing Therapeutic Targets for High-grade Neuroendocrine Lung Cancers Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25267614 Menin Determines K-RAS Proliferative Outputs in Endocrine Cells The Journal of Clinical Investigation. Sep, 2014 | Pubmed ID: 25133424 ERK5 Signaling Gets XIAPed: a Role for Ubiquitin in the Disassembly of a MAPK Cascade The EMBO Journal. Aug, 2014 | Pubmed ID: 25012518 Ras Transformation Uncouples the Kinesin-coordinated Cellular Nutrient Response Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25002494 Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation Science Signaling. May, 2014 | Pubmed ID: 24803536 G Protein-coupled Receptors and the Regulation of Autophagy Trends in Endocrinology and Metabolism: TEM. May, 2014 | Pubmed ID: 24751357 NeuroD1 Mediates Nicotine-induced Migration and Invasion Via Regulation of the Nicotinic Acetylcholine Receptor Subunits in a Subset of Neural and Neuroendocrine Carcinomas Molecular Biology of the Cell. Jun, 2014 | Pubmed ID: 24719457 Muscarinic Control of MIN6 Pancreatic β Cells is Enhanced by Impaired Amino Acid Signaling The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24695728 Regulation of OSR1 and the Sodium, Potassium, Two Chloride Cotransporter by Convergent Signals Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24191005 Off-target Effects of MEK Inhibitors Biochemistry. Aug, 2013 | Pubmed ID: 23848362 Minireview: Nutrient Sensing by G Protein-coupled Receptors Molecular Endocrinology (Baltimore, Md.). Aug, 2013 | Pubmed ID: 23820899 NeuroD1 Regulates Survival and Migration of Neuroendocrine Lung Carcinomas Via Signaling Molecules TrkB and NCAM Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23553831 Chromatin-tethered MAPKs Current Opinion in Cell Biology. Apr, 2013 | Pubmed ID: 23434067 Amino Acid Regulation of Autophagy Through the GPCR TAS1R1-TAS1R3 Autophagy. Mar, 2013 | Pubmed ID: 23222068 Protein Kinase WNK3 Regulates the Neuronal Splicing Factor Fox-1 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23027929 Interactions with WNK (with No Lysine) Family Members Regulate Oxidative Stress Response 1 and Ion Co-transporter Activity The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22989884 The G Protein-coupled Taste Receptor T1R1/T1R3 Regulates MTORC1 and Autophagy Molecular Cell. Sep, 2012 | Pubmed ID: 22959271 Signal Control Through Raf: in Sickness and in Health Cell Research. Jan, 2012 | Pubmed ID: 22143568 A Small Molecule Differentiation Inducer Increases Insulin Production by Pancreatic β Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22143803 WNK1 is Required for Mitosis and Abscission Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220314 Exposing Contingency Plans for Kinase Networks Cell. Dec, 2010 | Pubmed ID: 21145453 Calcineurin Increases Glucose Activation of ERK1/2 by Reversing Negative Feedback Proceedings of the National Academy of Sciences of the United States of America. Dec, 2010 | Pubmed ID: 21135229 Reconstitution of the Nuclear Transport of the MAP Kinase ERK2 Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20811989 Serum and Glucocorticoid-induced Kinase (SGK) 1 and the Epithelial Sodium Channel Are Regulated by Multiple with No Lysine (WNK) Family Members The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20525693 Regulation of CCAAT/enhancer-binding Protein Homologous Protein (CHOP) Expression by Interleukin-1 Beta in Pancreatic Beta Cells The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20424162 Multiple Chromatin-bound Protein Kinases Assemble Factors That Regulate Insulin Gene Transcription Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20018749 WNK Kinases and Blood Pressure Control Current Hypertension Reports. Dec, 2009 | Pubmed ID: 19895753 MAP-ping Unconventional Protein-DNA Interactions Cell. Oct, 2009 | Pubmed ID: 19879834 Radial Spoke Protein 3 is a Mammalian Protein Kinase A-anchoring Protein That Binds ERK1/2 The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19684019 FAK Phosphorylation by ERK Primes Ras-induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST Molecular Cell. Jul, 2009 | Pubmed ID: 19595712 Crystal Structure of Domain-swapped STE20 OSR1 Kinase Domain Protein Science : a Publication of the Protein Society. Feb, 2009 | Pubmed ID: 19177573 The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer Structure (London, England : 1993). Jan, 2009 | Pubmed ID: 19141286 PTMap--a Sequence Alignment Software for Unrestricted, Accurate, and Full-spectrum Identification of Post-translational Modification Sites Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009 | Pubmed ID: 19136633 Regulation of a Third Conserved Phosphorylation Site in SGK1 The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19068477 Sumoylation Regulates the Transcriptional Activity of MafA in Pancreatic Beta Cells The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19029092 Chromatin-bound Mitogen-activated Protein Kinases Transmit Dynamic Signals in Transcription Complexes in Beta-cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18755896 The Roles of MAPKs in Disease Cell Research. Apr, 2008 | Pubmed ID: 18347614 WNKs: Protein Kinases with a Unique Kinase Domain Experimental & Molecular Medicine. Oct, 2007 | Pubmed ID: 18059132 WNK1 is a Novel Regulator of Munc18c-syntaxin 4 Complex Formation in Soluble NSF Attachment Protein Receptor (SNARE)-mediated Vesicle Exocytosis The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17848561 Mutations in ERK2 Binding Sites Affect Nuclear Entry The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17656361 Differential Regulation of CHOP-10/GADD153 Gene Expression by MAPK Signaling in Pancreatic Beta-cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17615236 TAO Kinases Mediate Activation of P38 in Response to DNA Damage The EMBO Journal. Apr, 2007 | Pubmed ID: 17396146 Biological Cross-talk Between WNK1 and the Transforming Growth Factor Beta-Smad Signaling Pathway The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17392271 Mxi2 Promotes Stimulus-independent ERK Nuclear Translocation The EMBO Journal. Feb, 2007 | Pubmed ID: 17255949 Characterization of Mitogen-activated Protein Kinase (MAPK) Dimers Biochemistry. Nov, 2006 | Pubmed ID: 17073439 Expression and Characterization of MAP Kinases in Bacteria Methods (San Diego, Calif.). Nov, 2006 | Pubmed ID: 16908184 WNK1 and OSR1 Regulate the Na+, K+, 2Cl- Cotransporter in HeLa Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16832045 The Transcriptional ETS2 Repressor Factor Associates with Active and Inactive Erks Through Distinct FXF Motifs The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16799155 Role of With-no-lysine [K] Kinases in the Pathogenesis of Gordon's Syndrome Pediatric Nephrology (Berlin, Germany). Sep, 2006 | Pubmed ID: 16683163 The MAP Kinase ERK5 Binds to and Phosphorylates P90 RSK Archives of Biochemistry and Biophysics. May, 2006 | Pubmed ID: 16626623 The Nuclear Localization of ERK2 Occurs by Mechanisms Both Independent of and Dependent on Energy The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16595679 Cyclic AMP Selectively Uncouples Mitogen-activated Protein Kinase Cascades from Activating Signals Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16581779 Inhibition of Glucose-stimulated Activation of Extracellular Signal-regulated Protein Kinases 1 and 2 by Epinephrine in Pancreatic Beta-cells Diabetes. Apr, 2006 | Pubmed ID: 16567530 TGF-beta Regulation by Emilin1: New Links in the Etiology of Hypertension Cell. Mar, 2006 | Pubmed ID: 16530037 Activation of MEKK1 by Rho GTPases Methods in Enzymology. 2006 | Pubmed ID: 16472679 WNK1 Activates SGK1 by a Phosphatidylinositol 3-kinase-dependent and Non-catalytic Mechanism The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16081417 WNK1 Activates SGK1 to Regulate the Epithelial Sodium Channel Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 16006511 ERK1/2-dependent Activation of Transcription Factors Required for Acute and Chronic Effects of Glucose on the Insulin Gene Promoter The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15899886 Properties of WNK1 and Implications for Other Family Members The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15883153 Context-dependent Regulation of NeuroD Activity and Protein Accumulation Molecular and Cellular Neurosciences. Apr, 2005 | Pubmed ID: 15797719 WNK1: Analysis of Protein Kinase Structure, Downstream Targets, and Potential Roles in Hypertension Cell Research. Jan, 2005 | Pubmed ID: 15686619 Stimulus-coupled Spatial Restriction of Extracellular Signal-regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-response Pathways Molecular and Cellular Biology. Dec, 2004 | Pubmed ID: 15542825 Crystal Structure of the TAO2 Kinase Domain: Activation and Specificity of a Ste20p MAP3K Structure (London, England : 1993). Oct, 2004 | Pubmed ID: 15458637 WNK1 Phosphorylates Synaptotagmin 2 and Modulates Its Membrane Binding Molecular Cell. Sep, 2004 | Pubmed ID: 15350218 MAP Kinases and Their Roles in Pancreatic Beta-cells Cell Biochemistry and Biophysics. 2004 | Pubmed ID: 15289654 Protein Kinase Function and Glutathionylation The Biochemical Journal. Aug, 2004 | Pubmed ID: 15270699 Crystal Structure of the Kinase Domain of WNK1, a Kinase That Causes a Hereditary Form of Hypertension Structure (London, England : 1993). Jul, 2004 | Pubmed ID: 15242606 Structure of MAPKs Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 14755085 The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14707138 Characterization of OSR1, a Member of the Mammalian Ste20p/germinal Center Kinase Subfamily The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14707132 WNK1 Activates ERK5 by an MEKK2/3-dependent Mechanism The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14681216 RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14581471 MAP Kinase Modules: Many Roads Home Current Biology : CB. Nov, 2003 | Pubmed ID: 14614847 Regulation of Insulin Gene Transcription by ERK1 and ERK2 in Pancreatic Beta Cells The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12810726 Regulation of ERK1 and ERK2 by Glucose and Peptide Hormones in Pancreatic Beta Cells The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12783880 TAO (thousand-and-one Amino Acid) Protein Kinases Mediate Signaling from Carbachol to P38 Mitogen-activated Protein Kinase and Ternary Complex Factors The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12665513 Overview of the Alliance for Cellular Signaling Nature. Dec, 2002 | Pubmed ID: 12478301 Regulation of WNK1 by an Autoinhibitory Domain and Autophosphorylation The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12374799 Stimulus-specific Requirements for MAP3 Kinases in Activating the JNK Pathway The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12351623 Cell Condition-dependent Regulation of ERK5 by CAMP The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12297510 Binding of JNK/SAPK to MEKK1 is Regulated by Phosphorylation The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12228228 P115 Rho GTPase Activating Protein Interacts with MEKK1 Journal of Cellular Physiology. Aug, 2002 | Pubmed ID: 12115726 Crystal Structures of MAP Kinase P38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b Molecular Cell. Jun, 2002 | Pubmed ID: 12086621 The PHD Domain of MEKK1 Acts As an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2 Molecular Cell. May, 2002 | Pubmed ID: 12049732 ERK2 Enters the Nucleus by a Carrier-independent Mechanism Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 12032311 Sulindac Enhances Tumor Necrosis Factor-alpha-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-kappaB Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2002 | Pubmed ID: 11839649 Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1 The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11823456 Pharmacological Inhibitors of MAPK Pathways Trends in Pharmacological Sciences. Jan, 2002 | Pubmed ID: 11804650 Different Domains of the Mitogen-activated Protein Kinases ERK3 and ERK2 Direct Subcellular Localization and Upstream Specificity in Vivo The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11741894 Meten van relatieve insuline secretie met behulp van een co-afgescheiden Luciferase surrogaat Michael Kalwat1, Melanie H. Cobb1 1Department of Pharmacology, University of Texas Southwestern Medical Center JoVE 59926 Biologia
Meten van relatieve insuline secretie met behulp van een co-afgescheiden Luciferase surrogaat Michael Kalwat1, Melanie H. Cobb1 1Department of Pharmacology, University of Texas Southwestern Medical Center JoVE 59926 Biologia