Rajeev Gautam Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases National Institutes of Health Biography Publications Institution JoVE Articles Rajeev Gautam has not added a biography. If you are Rajeev Gautam and would like to personalize this page please email our Author Liaison for assistance. Publications Neutralizing Antibodies Induced in Immunized Macaques Recognize the CD4-binding Site on an Occluded-open HIV-1 Envelope Trimer Nature Communications. Feb, 2022 | Pubmed ID: 35136084 Sequential Immunization of Macaques Elicits Heterologous Neutralizing Antibodies Targeting the V3-glycan Patch of HIV-1 Env Science Translational Medicine. Nov, 2021 | Pubmed ID: 34818054 Antibody Elicited by HIV-1 Immunogen Vaccination in Macaques Displaces Env Fusion Peptide and Destroys a Neutralizing Epitope NPJ Vaccines. Oct, 2021 | Pubmed ID: 34697307 Immunotherapy During the Acute SHIV Infection of Macaques Confers Long-term Suppression of Viremia The Journal of Experimental Medicine. Jan, 2021 | Pubmed ID: 32966579 A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch ELife. Oct, 2020 | Pubmed ID: 33084569 Immunization Expands B Cells Specific to HIV-1 V3 Glycan in Mice and Macaques Nature. Jun, 2019 | Pubmed ID: 31142836 A Single Injection of Crystallizable Fragment Domain-modified Antibodies Elicits Durable Protection from SHIV Infection Nature Medicine. May, 2018 | Pubmed ID: 29662199 Potential of Conventional & Bispecific Broadly Neutralizing Antibodies for Prevention of HIV-1 Subtype A, C & D Infections PLoS Pathogens. Mar, 2018 | Pubmed ID: 29505593 Early Antibody Therapy Can Induce Long-lasting Immunity to SHIV Nature. Mar, 2017 | Pubmed ID: 28289286 DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV Journal of Immunology (Baltimore, Md. : 1950). Nov, 2016 | Pubmed ID: 27733554 A Single Injection of Anti-HIV-1 Antibodies Protects Against Repeated SHIV Challenges Nature. May, 2016 | Pubmed ID: 27120156 Quality and Quantity of TFH Cells Are Critical for Broad Antibody Development in SHIVAD8 Infection Science Translational Medicine. Jul, 2015 | Pubmed ID: 26223303 Pathogenic Features Associated with Increased Virulence Upon Simian Immunodeficiency Virus Cross-species Transmission from Natural Hosts Journal of Virology. Jun, 2014 | Pubmed ID: 24696477 Most Rhesus Macaques Infected with the CCR5-tropic SHIV(AD8) Generate Cross-reactive Antibodies That Neutralize Multiple HIV-1 Strains Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23129652 Pathogenicity and Mucosal Transmissibility of the R5-tropic Simian/human Immunodeficiency Virus SHIV(AD8) in Rhesus Macaques: Implications for Use in Vaccine Studies Journal of Virology. Aug, 2012 | Pubmed ID: 22647691 Rapid Development of Glycan-specific, Broad, and Potent Anti-HIV-1 Gp120 Neutralizing Antibodies in an R5 SIV/HIV Chimeric Virus Infected Macaque Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22123961 Pattern of SIVagm Infection in Patas Monkeys Suggests That Host Adaptation to Simian Immunodeficiency Virus Infection May Result in Resistance to Infection and Virus Extinction The Journal of Infectious Diseases. Nov, 2010 | Pubmed ID: 20887227 Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18981083 Acute Loss of Intestinal CD4+ T Cells is Not Predictive of Simian Immunodeficiency Virus Virulence Journal of Immunology (Baltimore, Md. : 1950). Sep, 2007 | Pubmed ID: 17709518 In Vitro Characterization of Primary SIVsmm Isolates Belonging to Different Lineages. In Vitro Growth on Rhesus Macaque Cells is Not Predictive for in Vivo Replication in Rhesus Macaques Virology. Jun, 2007 | Pubmed ID: 17303205 Gene Editing of Primary Rhesus Macaque B Cells Harald Hartweger1, Rajeev Gautam2, Yoshiaki Nishimura2, Fabian Schmidt3,5, Kai-Hui Yao1, Amelia Escolano1,6, Mila Jankovic1, Malcolm A. Martin2, Michel C. Nussenzweig1,4 1Laboratory of Molecular Immunology, The Rockefeller University, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 3Laboratory of Retrovirology, The Rockefeller University, 4Howard Hughes Medical Institute, The Rockefeller University, 5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST), 6Vaccine and Immunotherapy Center, Wistar Institute JoVE 64858 Imunologia e Infecção
Gene Editing of Primary Rhesus Macaque B Cells Harald Hartweger1, Rajeev Gautam2, Yoshiaki Nishimura2, Fabian Schmidt3,5, Kai-Hui Yao1, Amelia Escolano1,6, Mila Jankovic1, Malcolm A. Martin2, Michel C. Nussenzweig1,4 1Laboratory of Molecular Immunology, The Rockefeller University, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 3Laboratory of Retrovirology, The Rockefeller University, 4Howard Hughes Medical Institute, The Rockefeller University, 5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST), 6Vaccine and Immunotherapy Center, Wistar Institute JoVE 64858 Imunologia e Infecção