Thijn R. Brummelkamp Oncode Institute and Division of Biochemistry Netherlands Cancer Institute Biography Publications Institution JoVE Articles Thijn R. Brummelkamp has not added a biography. If you are Thijn R. Brummelkamp and would like to personalize this page please email our Author Liaison for assistance. Publications Actin Maturation Requires the ACTMAP/C19orf54 Protease Science (New York, N.Y.). Sep, 2022 | Pubmed ID: 36173861 The Cohesin Acetylation Cycle Controls Chromatin Loop Length Through a PDS5A Brake Mechanism Nature Structural & Molecular Biology. Jun, 2022 | Pubmed ID: 35710836 Posttranslational Modification of Microtubules by the MATCAP Detyrosinase Science (New York, N.Y.). May, 2022 | Pubmed ID: 35482892 A Mediator-cohesin Axis Controls Heterochromatin Domain Formation Nature Communications. Feb, 2022 | Pubmed ID: 35136067 E3 Ubiquitin Ligase Mindbomb 1 Facilitates Nuclear Delivery of Adenovirus Genomes Proceedings of the National Academy of Sciences of the United States of America. Jan, 2021 | Pubmed ID: 33443154 The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses Immunity. Jan, 2021 | Pubmed ID: 33271119 Quantitative Genetic Screening Reveals a Ragulator-FLCN Feedback Loop That Regulates the MTORC1 Pathway Science Signaling. Sep, 2020 | Pubmed ID: 32934076 Regulates the Action of Nitrogen-containing Bisphosphonates on Bone Science Translational Medicine. May, 2020 | Pubmed ID: 32434850 Haploid Genetic Screens Identify SPRING/C12ORF49 As a Determinant of SREBP Signaling and Cholesterol Metabolism Nature Communications. Feb, 2020 | Pubmed ID: 32111832 A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 As Factors Supporting Vaccinia Virus Infection Journal of Virology. Jul, 2019 | Pubmed ID: 30996093 Glutaminyl Cyclase is an Enzymatic Modifier of the CD47- SIRPα Axis and a Target for Cancer Immunotherapy Nature Medicine. Apr, 2019 | Pubmed ID: 30833751 SLFN11 Can Sensitize Tumor Cells Towards IFN-γ-mediated T Cell Killing PloS One. 2019 | Pubmed ID: 30753225 BRCA2 Deficiency Instigates CGAS-mediated Inflammatory Signaling and Confers Sensitivity to Tumor Necrosis Factor-alpha-mediated Cytotoxicity Nature Communications. Jan, 2019 | Pubmed ID: 30626869 The Tubulin Detyrosination Cycle: Function and Enzymes Trends in Cell Biology. Jan, 2019 | Pubmed ID: 30213517 Protocadherin-1 is Essential for Cell Entry by New World Hantaviruses Nature. 11, 2018 | Pubmed ID: 30464266 LZTR1 is a Regulator of RAS Ubiquitination and Signaling Science (New York, N.Y.). Dec, 2018 | Pubmed ID: 30442766 Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma Cancer Research. Dec, 2018 | Pubmed ID: 30213788 Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores Current Biology : CB. Sep, 2018 | Pubmed ID: 30122526 Viral Escape from Endosomes and Host Detection at a Glance Journal of Cell Science. Aug, 2018 | Pubmed ID: 30076240 Haploid Genetic Screens Identify Genetic Vulnerabilities to Microtubule-targeting Agents Molecular Oncology. Jun, 2018 | Pubmed ID: 29689640 KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses Cell Host & Microbe. May, 2018 | Pubmed ID: 29681460 BUB1 Is Essential for the Viability of Human Cells in Which the Spindle Assembly Checkpoint Is Compromised Cell Reports. Feb, 2018 | Pubmed ID: 29425499 NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry Cell Host & Microbe. Nov, 2017 | Pubmed ID: 29120745 Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread Cell Host & Microbe. Oct, 2017 | Pubmed ID: 29024641 Identification of CMTM6 and CMTM4 As PD-L1 Protein Regulators Nature. Sep, 2017 | Pubmed ID: 28813410 Genetic Wiring Maps of Single-cell Protein States Reveal an Off-switch for GPCR Signalling Nature. Jun, 2017 | Pubmed ID: 28562590 The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension Cell. May, 2017 | Pubmed ID: 28475897 A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles MSphere. 2016 | Pubmed ID: 27303731 Enterovirus D68 Receptor Requirements Unveiled by Haploid Genetics Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016 | Pubmed ID: 26787879 A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection Journal of Virology. Feb, 2016 | Pubmed ID: 26581979 Filovirus Receptor NPC1 Contributes to Species-specific Patterns of Ebolavirus Susceptibility in Bats ELife. 2015 | Pubmed ID: 26698106 Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation Chemistry & Biology. Dec, 2015 | Pubmed ID: 26687144 A Generic Strategy for CRISPR-Cas9-mediated Gene Tagging Nature Communications. Dec, 2015 | Pubmed ID: 26674669 Subunit Composition of VRAC Channels Determines Substrate Specificity and Cellular Resistance to Pt-based Anti-cancer Drugs The EMBO Journal. Dec, 2015 | Pubmed ID: 26530471 Gene Essentiality and Synthetic Lethality in Haploid Human Cells Science (New York, N.Y.). Nov, 2015 | Pubmed ID: 26472760 Compromising the 19S Proteasome Complex Protects Cells from Reduced Flux Through the Proteasome ELife. Sep, 2015 | Pubmed ID: 26327695 Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer Cancer Research. Oct, 2015 | Pubmed ID: 26260527 Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion MBio. Jun, 2015 | Pubmed ID: 26126854 GENE REGULATION. A HUSH for Transgene Expression Science (New York, N.Y.). Jun, 2015 | Pubmed ID: 26113708 Niemann-pick C1 is Essential for Ebolavirus Replication and Pathogenesis in Vivo MBio. May, 2015 | Pubmed ID: 26015498 Emerging Intracellular Receptors for Hemorrhagic Fever Viruses Trends in Microbiology. Jul, 2015 | Pubmed ID: 26004032 Megabase-scale Deletion Using CRISPR/Cas9 to Generate a Fully Haploid Human Cell Line Genome Research. Dec, 2014 | Pubmed ID: 25373145 The Solute Carrier SLC35F2 Enables YM155-mediated DNA Damage Toxicity Nature Chemical Biology. Sep, 2014 | Pubmed ID: 25064833 GPR107, a G-protein-coupled Receptor Essential for Intoxication by Pseudomonas Aeruginosa Exotoxin A, Localizes to the Golgi and is Cleaved by Furin The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 25031321 USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen Cancer Research. Jul, 2014 | Pubmed ID: 25028367 Virus Entry. Lassa Virus Entry Requires a Trigger-induced Receptor Switch Science (New York, N.Y.). Jun, 2014 | Pubmed ID: 24970085 Caspase-mediated Cleavage of Phospholipid Flippase for Apoptotic Phosphatidylserine Exposure Science (New York, N.Y.). Jun, 2014 | Pubmed ID: 24904167 LRP1 is a Receptor for Clostridium Perfringens TpeL Toxin Indicating a Two-receptor Model of Clostridial Glycosylating Toxins Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24737893 Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells Cell Reports. Apr, 2014 | Pubmed ID: 24685140 A Reversible Gene Trap Collection Empowers Haploid Genetics in Human Cells Nature Methods. Oct, 2013 | Pubmed ID: 24161985 Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry Science (New York, N.Y.). Apr, 2013 | Pubmed ID: 23519211 Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T Helper Type 2)-associated Adjuvants The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23297415 Ebola Virus Entry Requires the Host-programmed Recognition of an Intracellular Receptor The EMBO Journal. Apr, 2012 | Pubmed ID: 22395071 Suppression of the P53-dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling Molecular Cancer Research : MCR. Sep, 2008 | Pubmed ID: 18723828 ShRNA Libraries and Their Use in Cancer Genetics Nature Methods. Sep, 2006 | Pubmed ID: 16929315 An ShRNA Barcode Screen Provides Insight into Cancer Cell Vulnerability to MDM2 Inhibitors Nature Chemical Biology. Apr, 2006 | Pubmed ID: 16474381 A Genomic and Functional Inventory of Deubiquitinating Enzymes Cell. Dec, 2005 | Pubmed ID: 16325574 Functional Annotation of Deubiquitinating Enzymes Using RNA Interference Methods in Enzymology. 2005 | Pubmed ID: 16275358 The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway Molecular Cell. Feb, 2005 | Pubmed ID: 15694335 A Large-scale RNAi Screen in Human Cells Identifies New Components of the P53 Pathway Nature. Mar, 2004 | Pubmed ID: 15042092 Human Immunodeficiency Virus Type 1 Escapes from RNA Interference-mediated Inhibition Journal of Virology. Mar, 2004 | Pubmed ID: 14963165 New Tools for Functional Mammalian Cancer Genetics Nature Reviews. Cancer. Oct, 2003 | Pubmed ID: 14570045 Loss of the Cylindromatosis Tumour Suppressor Inhibits Apoptosis by Activating NF-kappaB Nature. Aug, 2003 | Pubmed ID: 12917690 Specific Inhibition of Gene Expression Using a Stably Integrated, Inducible Small-interfering-RNA Vector EMBO Reports. Jun, 2003 | Pubmed ID: 12776180 Stable Suppression of Tumorigenicity by Virus-mediated RNA Interference Cancer Cell. Sep, 2002 | Pubmed ID: 12242156 Una Pantalla De La Senectud Rescate Identifica BCL6 Como Inhibidor De La Anti-proliferativa P19 (FRA)-p53 De Señalización Genes & Development. Mar, 2002 | Pubmed ID: 11914273 A System for Stable Expression of Short Interfering RNAs in Mammalian Cells Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11910072 TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, is a Negative Regulator of P19ARF and Inhibits Senescence The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11748239 Crystal Structure of the Tubulin Tyrosine Carboxypeptidase Complex VASH1-SVBP Nature Structural & Molecular Biology. | Pubmed ID: 31270470 Vasohibins Encode Tubulin Detyrosinating Activity Science (New York, N.Y.). | Pubmed ID: 29146869 PLA2G16 Represents a Switch Between Entry and Clearance of Picornaviridae Nature. | Pubmed ID: 28077878 Extracción de microtúbulos modificados de células de mamíferos para estudiar complejos microtúbulos-proteínas mediante microscopía crioelectrónica Jitske Bak1, Lisa Landskron1, Thijn R. Brummelkamp1, Anastassis Perrakis1 1Oncode Institute and Division of Biochemistry, Netherlands Cancer Institute JoVE 65126 Bioquímica
Extracción de microtúbulos modificados de células de mamíferos para estudiar complejos microtúbulos-proteínas mediante microscopía crioelectrónica Jitske Bak1, Lisa Landskron1, Thijn R. Brummelkamp1, Anastassis Perrakis1 1Oncode Institute and Division of Biochemistry, Netherlands Cancer Institute JoVE 65126 Bioquímica