20.13
Reatividade de Radicais: Intramolecular vs Intermolecular
As reações radicais podem ocorrer intermolecularmente ou intramolecularmente. Em uma reação radical intermolecular, um radical nucleofílico se adicion…
Nas reações radicais intermoleculares, o radical e a armadilha radical são duas moléculas diferentes.
A armadilha radical deve ser ativada e presente em altas concentrações, e a fonte radical deve ter uma ligação carbono-heteroátomo fraca.
Agora, considere uma reação de radical intramolecular, na qual um radical nucleofílico se adiciona a uma ligação dupla nucleofílica, produzindo um produto ciclizado.
Aqui, a armadilha radical não é ativada nem está presente em excesso. A ligação C-S também é relativamente forte.
Ainda assim, tal reação é viável, proporcionando um alto rendimento do produto. Por quê?
Isso porque, para reações intramoleculares, o radical e a armadilha radical fazem parte da mesma molécula e são sempre mantidos próximos, favorecendo a ciclização rápida.
Consequentemente, a possibilidade de redução radical por um doador de hidreto diminui.
Além disso, a armadilha radical não é altamente reativa nem em excesso, reduzindo suas chances de reagir com o radical hidreto de estanho, independentemente da concentração deste último.
Portanto, as reações radicais intramoleculares são muito eficientes e encontram aplicações na síntese de anéis de cinco membros. Tamanhos de anel menores exibem tensão do anel. Tamanhos de anéis maiores não são preferidos.
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Q1: What are the key differences between intermolecular and intramolecular radical reactions?
In intermolecular radical reactions, the radical and radical trap are separate molecules, requiring the trap to be activated and present in high concentration. In intramolecular reactions, both are part of the same molecule, held closely together, enabling rapid cyclization without needing activation or excess concentration. This proximity makes intramolecular reactions far more efficient.
Q2: Why do intramolecular radical reactions proceed efficiently despite having strong carbon-heteroatom bonds?
Intramolecular reactions are efficient because the radical and radical trap are part of the same molecule, keeping them in close proximity. This favors rapid cyclization and prevents radical reduction by hydride donors. The radical trap, being neither highly reactive nor in excess, resists competing reactions with tributyltin hydride radicals, ensuring high product yield.
Q3: What ring sizes are preferred in intramolecular radical cyclization reactions?
Five-membered rings are the preferred product of intramolecular radical cyclization. Smaller ring sizes experience significant ring strain, making them unfavorable. Larger ring sizes are also not preferred, as they reduce the efficiency of the cyclization process and lower product yields.
Q4: How does molecular proximity affect the outcome of intramolecular radical reactions?
Molecular proximity is crucial in intramolecular reactions because the radical and radical trap remain held closely together within the same molecule. This close association dramatically increases the rate of cyclization and minimizes side reactions. The result is rapid, efficient bond formation with minimal competing pathways.
Q5: What conditions must be met for intermolecular radical reactions to occur successfully?
Intermolecular radical reactions require three key conditions: the radical trap must be activated, present in high concentration, and the radical source must have a weak carbon-halogen bond. These requirements ensure sufficient collision frequency and reactivity between separate molecules to generate acceptable product yields.
Q6: How does the presence of a hydride donor affect intramolecular versus intermolecular radical reactions?
In intermolecular reactions, hydride donors can reduce radicals, competing with trap addition and lowering yields. In intramolecular reactions, rapid cyclization minimizes the opportunity for hydride reduction. Additionally, the radical trap's low reactivity and lack of excess concentration reduce its competition with hydride donors, preserving reaction efficiency.
Q7: Why is the concentration of the radical trap critical in intermolecular but not intramolecular radical reactions?
In intermolecular reactions, high radical trap concentration increases collision probability with the radical, driving product formation. In intramolecular reactions, the trap is already bound to the radical within the same molecule, eliminating the need for high concentration. This inherent proximity ensures efficient reaction regardless of bulk concentration.