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JoVE Journal Cancer Research

Cytometer Assays of MPNST Cells Challenged with Therapeutic Agents

High-Throughput Screening of CAR T-Cell Constructs for Enhanced Cytotoxicity and Immunologic Memory (Video) | JoVE

Journal (Cancer Research)

High-Throughput Screening of CAR T-Cell Constructs for Enhanced Cytotoxicity and Immunologic Memory (Video) | JoVE

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Journal (Cancer Research)

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Cytometer Assays of MPNST Cells Challenged with Therapeutic Agents

Genome-Scale Screening to Identify and Compare Therapeutic Targets in Tumors

Article DOI: 10.3791/200479-v • 01:30 min • August 25th, 2023

August 25th, 2023 •

Brittany Turner-Ivey¹, Jody Fromm Longo², Dorea P. Jenkins², Stephen T. Guest³, Steven L. Carroll^1,2

¹Hollings Cancer Center, Medical University of South Carolina, ²Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ³Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor

Tags

Genetic Profiling Genome-scale Dropout Screening Therapeutic Targets Mouse Models Malignant Peripheral Nerve Sheath Tumor Schwann Cells Neurofibromatosis Type 1 (NF1) Soft-tissue Sarcoma Disease-free Survival Rates Treatment Options Disfiguring Surgery Tipifarnib Ras Signaling Inhibitor Erlotinib Epidermal Growth Factor (EGFR) Inhibitor Sorafenib Vascular Endothelial Growth Factor Receptor (VEGF) Inhibitor Platelet-derived Growth Factor Receptor (PDGF) Inhibitor Raf Inhibitor Functional Genomic Screening Cancer Cell Lines Cytoplasmic Signaling Pathways Target-specific Therapies

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