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Immunology and Infection

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JoVE Journal Immunology and Infection
Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice

Article DOI: 10.3791/2357-v • 10:48 min • April 14th, 2011
April 14th, 2011 •
1, 2, 1, 1, 3, 1, 1
1Department of Microbiology and Immunology, University of Melbourne, 2Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, 3The Centre for Dynamic Imaging, The Walter and Eliza Hall Institute for Medical Research

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A concurrent infection with influenza A virus is one of the factors implicated in the induction of invasive pneumococcal disease during asymptomatic Streptococcus pneumoniae carriage. Here we describe a mixed infection method using infant mice to investigate the synergism between these two respiratory pathogens.

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Bioluminescent Imaging Synergism Streptococcus Pneumoniae Influenza A Virus Infant Mice 1918 Influenza Pandemic Secondary Bacterial Infection Pneumococcus 1957 Asian Influenza Pandemic Seasonal Outbreaks Morbidity Concurrent Infection Murine Model Influenza Virus Infection S. Pneumoniae Colonization Kinetics In Vivo Imaging
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