Olfactory Assays for Mouse Models of Neurodegenerative Disease

Andrew M. Lehmkuhl; Emily R. Dirr; Sheila M. Fleming

doi:10.3791/51804

Journal

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Neurociência

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Ensaios olfativas para o Rato modelos de doenças neurodegenerativas

Olfactory Assays for Mouse Models of Neurodegenerative Disease

JoVE Journal
Neurociência

This content is Free Access.

JoVE Journal Neurociência

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Ensaios olfativas para o Rato modelos de doenças neurodegenerativas

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21,897 Views

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07:27 min

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August 25, 2014

DOI:

10.3791/51804-v

DOI:

10.3791/51804-v

•

07:27 min

August 25, 2014

•

13 Views

Andrew M. Lehmkuhl¹, Emily R. Dirr^2,3, Sheila M. Fleming^1,2

¹Department of Psychology,University of Cincinnati, ²Department of Neurology,University of Cincinnati, ³Department of Neuroscience, Cell Biology, and Physiology,Wright State University

Summary

Impairment in olfactory function is a common feature in many neurodegenerative disorders including Parkinson, Alzheimer, and Huntington diseases. In the present article, we describe a set of tests for assessing olfaction discrimination and detection in mice that can be used to measure olfactory abilities in mouse models of neurodegenerative diseases.