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Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films

Article DOI: 10.3791/52971-v • 12:03 min • June 26th, 2015
June 26th, 2015 •
1, 1, 1, 1, 1
1Department of Biomedical Engineering, University of Minnesota

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We present a method for microfluidic deposition of patterned genipin and fibronectin on PDMS substrates, allowing extended viability of vascular smooth muscle cell-dense tissues. This tissue fabrication method is combined with previous vascular muscular thin film technology to measure vascular contractility over disease-relevant time courses.

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Microfluidic Genipin Deposition Technique Extended Culture Micropatterned Vascular Muscular Thin Films Vascular Disease Progression Physiologic And Pathologic Vascular Behaviors Microcontact Printing Two-dimensional Functional Arterial Mimics Extracellular Matrix Protein Guidance Cues Tissue Organization Hydrophobic PDMS Substrates Tissue Turnover Conformational Change Denaturing Hydrophobic Amino Acid Residues Attachment Matrix Protein Bioactivity Delamination Death Of Tissues Crosslinker Compound Genipin Intermediary Newly-synthesized Extracellular Matrix Protein Hydrophilic Surface Dictation Of Engineered Tissue Structure
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