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JoVE Journal Cancer Research
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy
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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Article DOI: 10.3791/56583-v • 08:59 min • December 11th, 2017
December 11th, 2017 •
1, 1, 1, 1, 1, 2, 1
1Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 2Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS

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This is a time- and cost-effective in vitro protocol investigating the mechanisms of acquired resistance to targeted therapeutic agents, which is a highly unmet medical need in cancer management.

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Driver Pathways Acquired Resistance Targeted Therapy Drug Resistant Subclone Generation Gene Knock-down Preclinical Platform Genome Drive Tumor Heterogeneity Resistance Mechanisms Time And Cost-effective Approach Lung Resistance Emerging Targeted Therapies Conventional Chemotherapeutic Agents Drug-resistant Subclones Standardize Trastuzumab HER-positive Gastric Cancer Cell Lines
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