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Journal / Neuroscience / 利用瞬态受体电位辣椒1型 Ultrapotent…
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JoVE Journal Neuroscience
利用瞬态受体电位辣椒1型 Ultrapotent 激动剂建立单纯小纤维神经病变的小鼠模型
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利用瞬态受体电位辣椒1型 Ultrapotent 激动剂建立单纯小纤维神经病变的小鼠模型

Article DOI: 10.3791/56651-v • 09:39 min • February 13th, 2018
February 13th, 2018 •
1,2, 3, 1,2
1Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, 2Department of Medical Research, Kaohsiung Medical University Hospital, 3Department of Medical Research, Ultrastructural Laboratory, Kaohsiung Medical University Hospital

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本研究建立了树酯毒素 (RTX) 纯小纤维神经病变的实验模型。独特剂量的 RTX (50 µg/千克) 是最佳的发展一个小纤维神经病变模型, 模仿病人的特点, 并可以帮助调查的伤害性分子意义下的神经病理性疼痛。

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神经科学 问题 132 树酯毒素 (RTX) 冯弗雷头发灯丝 热板测试 机械痛觉 热 hypoalgesia 瞬态受体电位辣椒型 1 (TRPV1) 小纤维神经病变 神经损伤 活化转录factor-3 (ATF3)
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