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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Article DOI: 10.3791/58148-v • 11:17 min • August 30th, 2018
August 30th, 2018 •
1, 1, 1, 1, 1, 1
1Institute of Laboratory Medicine, University Hospital, LMU Munich

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Here we present a tandem mass spectrometry-based protocol for the quantification of frequently used antibiotics in intensive care units, namely cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid, and piperacillin.

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Multiplex Therapeutic Drug Monitoring Isotope-dilution HPLC-MS/MS Antibiotics Critical Illnesses Antibiotic Stewardship Programs Medical Facilities Quantification Of Antibiotics Dosage Adjustment Pathogen Susceptibility Mass Spectrometry-based Protocol Intensive Care Units Cefepime Meropenem Ciprofloxacin Moxifloxacin Linezolid Piperacillin Pharmacokinetic Area Under The Curve Turnaround Time Serum Calibrators Quality Controls
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