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A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Article DOI: 10.3791/61076-v • 08:28 min • May 21st, 2020
May 21st, 2020 •
1, 1, 1, 1
1Department of Biomedical Engineering, The University of Akron

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Here, we present protocols for analyzing bone remodeling within a lab-on-a-chip platform. A 3D printed mechanical loading device can be paired with the platform to induce osteocyte mechanostransduction by deforming the cellular matrix. The platform can also be used to quantify bone remodeling functional outcomes from osteoclasts and osteoblasts (resorption/formation).

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Lab-On-A-Chip Osteocyte Mechanotransduction Bone Remodeling Bone Cells Culturing Bone Formation Bone Resorption Mechanical Loading Environments Osteoporosis Fracture Healing Periprosthetic Osteolysis PDMS Prepolymer Curing Agent Microchannel Layer PDMS Membrane Layer
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