Implantação e Controle de Sistemas Sem Fio e Sem Bateria para Interface de Nervos Periféricos

9.3K visualizações

Citado por 4

07:13 min.

20 de outubro de 2021

10.3791/63085-v

20 de outubro de 2021

9.3K visualizações

Hongkai Wang¹^,² , Dom D’Andrea¹ , Yeon Sik Choi³^,⁴ , Yasmine Bouricha¹ , Grace Wickerson³^,⁴ , Hak-Young Ahn³ , Hexia Guo³^,⁴ , Yonggang Huang³^,⁴^,⁵^,⁶ , Milap S. Sandhu⁷ , Sumanas W. Jordan⁸ , John A. Rogers³^,⁴^,⁶^,⁹^,¹⁰^,¹¹^,¹² , Colin K. Franz¹^,³^,¹³

¹Laboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ²Northwestern University Interdepartmental Neuroscience Program, ³Center for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University, ⁴Department of Materials Science and Engineering, Northwestern University, ⁵Department of Civil and Environmental Engineering, Northwestern University, ⁶Department of Mechanical Engineering, Northwestern University, ⁷Arms and Hands Lab, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ⁸Division of Plastic and Reconstructive Surgery, Biologics, Shirley Ryan AbilityLab, Northwestern University, ⁹Department of Biomedical Engineering, Northwestern University, ¹⁰Department of Neurological Surgery, Northwestern University, ¹¹Department of Chemistry, Northwestern University, ¹²Department of Electrical and Computer Engineering, Northwestern University, ¹³The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine

Este é um protocolo para o implante cirúrgico e operação de uma interface sem fio para nervos periféricos. Demonstramos a utilidade dessa abordagem com exemplos de estimuladores de nervo colocados no nervo ciático ou frênico de ratos.

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Interface de Nervo Periférico

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Implante Sem Bateria

Modelo de Nervo Ciático

Modelo de Nervo Frênico

Estimulação Elétrica

Potenciais de Ação Muscular Compostos

Regeneração Nervosa

Transferência de Energia Indutiva

Análise de Eletromiografia

Chapters in this video

0:00

Introduction

0:58

Surgical Procedure for Implantation of a Wireless, Battery‐Free Peripheral Nerve Interface on the Right Sciatic Nerve of the Rat for Electrical Stimulation

3:07

Surgical Procedure for the Implantation of Wireless Stimulators on the Left Phrenic Nerve of the Rat

4:46

Wireless Delivery of Therapeutic Electrical Stimulation

5:29

Results: Nerve Conduction Studies, EMG Recording, and Nerve Regeneration in the Sciatic Nerve Injury Model

6:42

Conclusion