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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Article DOI: 10.3791/64611-v • 03:57 min • July 14th, 2023
July 14th, 2023 •
*1, *2, 1, 1, 1, 3, 2, 1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, 2State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, 3Guangdong Province Key Laboratory of Stomatology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University
* These authors contributed equally

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An animal model of acquired hypoparathyroidism (HypoPT) is crucial to understanding how HypoPT affects mineral ion homeostasis and to verify the effectiveness of novel treatments. Here, a technique is presented to generate an acquired hypoparathyroidism (AHypoPT) rat model by parathyroidectomy (PTX) using carbon nanoparticles.

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Hypoparathyroid Rats Carbon Nanoparticles Parathyroidectomy Rat Model Acquired Hypoparathyroidism Thyroid Glands Calcium And Vitamin D Post-thyroidectomy Hypocalcemia Bone Turnover PTH Analogs Stereo Microscope Anesthetized Rat Ventral Neck Region Carbon Nanoparticle Suspension Thyroid Gland Membrane Saline Irrigation Unstained Parathyroid Glands Microsurgical Technique
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