Cis Trans Conformation
Cis Trans Conformation - Related Videos
02:37
Disubstituted Cyclohexanes: cis-trans Isomerism
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2023
Depending upon the different spatial orientation of the substituents, the disubstituted cycloalkanes exhibit two types of stereoisomers. The cis isomers have the substituents on the same side of the ring, whereas the trans isomers have the substituents on the opposite sides. These stereoisomers exhibit different physical properties and cannot be interconverted without breaking the carbon-carbon bonds. In cyclohexane, the substituents can occupy different positions generating distinct isomers.
10:37
Spatial Separation of Molecular Conformers and Clusters
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Cited by 3 •
2014
We present a technique that allows the spatial separation of different conformers or clusters present in a molecular beam. An electrostatic deflector is used to separate species by their mass-to-dipole moment ratio, leading to the production of gas-phase ensembles of a single conformer or cluster stoichiometry.
02:02
Cis-regulatory Sequences
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2020
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
01:20
Conformity
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2020
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group. Asch’s Original Study Solomon Asch conducted several experiments in the 1950s to determine how people are affected by the thoughts and behaviors of other people. In one study, a group of participants was shown a series of printed line segments of different lengths: a, b, and c. Participants were then shown a fourth line segment: x. They were asked to identify which...
05:48
Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cited by 3 •
2018
Complexity of in vivo systems makes it difficult to distinguish between the activation and inhibition of Notch receptor by trans- and cis-ligands, respectively. Here, we present a protocol based on in vitro cell-aggregation assays for qualitative and semi-quantitative evaluation of the binding of Drosophila Notch to trans-ligands vs cis-ligands.
FAQs
Persistence arises because the carbon-carbon double bond restricts rotation. Substituents therefore remain in a defined relative arrangement instead of freely exchanging positions, allowing distinct geometric forms to be considered separately. This fixed stereochemical relationship helps explain why molecules with the same atomic connections can display different shapes, polarity, stability, or reactivity.
Changing substituents from the same side to opposite sides alters the molecule’s three-dimensional shape and can change how its polar features are distributed. Those structural differences may affect overall polarity, which in turn contributes to differences in physical behavior and chemical response. Comparing both arrangements is therefore important when interpreting molecular properties.
A ring framework limits how attached groups can orient relative to one another. Groups may consequently occupy comparable same-side or opposite-side relationships within the constrained structure, producing geometric alternatives even when the key structural feature is a ring. The ring’s restricted geometry makes relative orientation an important part of stereochemical analysis.
Chemists examine the relative positions of substituents to distinguish geometric forms that share the same molecular connections. Assigning a cis or trans relationship provides structural information beyond a two-dimensional connectivity formula. That assignment can then support comparisons of molecular shape, polarity, stability, boiling point, and reactivity between the forms.
The comparison should focus on how each arrangement affects the molecule’s properties and chemical behavior. Differences in shape, polarity, stability, boiling point, and reactivity can help researchers evaluate or interpret products associated with a synthesis. Treating the forms as structurally distinct is especially useful when stereochemical outcomes are part of the analysis.
Relative substituent orientation can change the shape and other properties of biologically active molecules. For fatty acids and pharmaceutical compounds, those structural differences provide relevant stereochemical context when researchers examine behavior, activity, or molecular characterization. The cis-trans relationship therefore connects geometric structure with the study of biologically important chemical systems.