Porous Hydrogels
Porous Hydrogels - Related Videos
06:36
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
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Cited by 23 •
2019
The three critical steps of this protocol are i) developing the right composition and consistency of the cellulose hydrogel ink, ii) 3D printing of scaffolds into various pore structures with good shape fidelity and dimensions and iii) demonstration of the mechanical properties in simulated body conditions for cartilage regeneration.
07:25
Collagen Hydrogels
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2023
Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...
07:32
Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
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Cited by 10 •
2017
This paper reports practical methods to prepare hydrogels in freestanding films and impregnated membranes and to characterize their physical properties, including water transport properties.
08:33
Hydrogel Synthesis
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2023
Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
15:06
Synthesis of an Intein-mediated Artificial Protein Hydrogel
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Cited by 2 •
2014
We present the synthesis of a split-intein-mediated protein hydrogel. The building blocks of this hydrogel are two protein copolymers each containing a subunit of a trimeric protein that serves as a crosslinker and one half of a split intein. Mixing of the two protein copolymers triggers an intein trans-splicing reaction, yielding a polypeptide unit that self-assembles into a hydrogel. This hydrogel is highly pH- and temperature-stable, compatible with organic solvents, and easily incorporates...
FAQs
Hydrophilic functional groups attract water into the polymer network. As water enters, hydration forces expand the chains, while crosslinks resist unlimited expansion. This balance determines swelling and influences pore dimensions, diffusion pathways, and mechanical response. In chemistry, changing functional-group composition provides a way to tune how the material interacts with aqueous molecules and biological environments.
Crosslinking density sets how strongly polymer chains are held together. Higher density generally restricts chain movement and swelling, whereas lower density permits greater expansion but can reduce structural stability. Because crosslinks and pores jointly govern fluid movement, researchers adjust this variable alongside polymer composition rather than treating permeability and mechanical behavior as independent properties.
Pore size determines the available pathways for fluid transport and molecular diffusion. Larger interconnected pores can facilitate movement, while smaller pores impose greater geometric restrictions. The outcome also depends on polymer composition and crosslinking, which affect swelling and network rigidity. Controlling these variables together helps match permeability and mechanical behavior to a specific chemical or biological use.
Responsive porous hydrogels change their swelling or transport properties when environmental conditions vary. A change in pH, temperature, or chemical composition can alter interactions within the polymer network, modifying its water uptake and effective pathways for molecular movement. Such responsiveness allows researchers to design materials whose permeability or other transport behavior changes under selected conditions.
Design begins by selecting a suitable polymer composition and then adjusting pore size, crosslinking density, and hydrophilic functionality. These choices influence swelling, permeability, molecular diffusion, and mechanical behavior. Researchers can therefore balance transport with structural integrity rather than optimizing only one property, creating a network suited to the intended chemical, biological, or separation environment.
In drug delivery, interconnected pores and adjustable swelling can provide environments that regulate fluid movement and molecular diffusion. For tissue engineering, the hydrated network offers a tunable setting for interactions with biological systems and cells. Varying polymer composition, pore structure, and crosslinking helps adapt transport and mechanical behavior to the requirements of each application.
Their water-rich, interconnected structure supports interactions between dissolved molecules and the polymer network. In biosensing, this environment can help present a responsive material to biological or chemical conditions. In separation processes, adjustable pore structure and permeability can influence molecular transport. These uses rely on controlling composition, swelling, and crosslinking to produce selective transport behavior.