Alcohol Ablation
Alcohol Ablation - Related Videos
12:19
Identifying Alcohols - Student Protocol
0 Views •
2020
Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA Ferric Chloride Test for PhenolsExpand In this lab, you will identify an unknown alcohol using the ferric chloride test, the Jones test, and the Lucas test. You'll test known alcohols alongside the unknown alcohol as examples of positive and negative results for each test. The four known alcohols are 1-butanol, a primary alcohol, 2-butanol, a secondary alcohol, 2-methyl-2-propanol, a tertiary...
03:32
Identifying Alcohols - Concepts
0 Views •
2020
Alcohols Alcohols are organic compounds that are amongst the most recognizable and familiar, as they have wide-ranging applications and uses in everyday life. Alcohols are organic molecules containing a hydroxyl functional group connected to an alkyl or aryl group (ROH). If the hydroxyl carbon only has a single R group, it is known as primary alcohol. If it has two R groups, it is a secondary alcohol, and if it has three R groups, it is a tertiary alcohol. Like many other organic compounds,...
07:25
Identifying Alcohols - Instructor Prep
0 Views •
2020
Source: Lara Al Hariri at the University of Massachusetts Amherst, MA, USA Preparation of ReagentsExpand Here, we show the laboratory preparation for 10 students working in pairs, with some excess. Please adjust quantities as needed. Before you begin, put on a lab coat, safety glasses, and nitrile gloves, and set up a waste container for aqueous chromium, iron, and zinc waste. Note: Work in a fume hood because the reagents are acidic, toxic, and corrosive. The reagents undergo...
11:21
Robotic Ablation of Atrial Fibrillation
0 Views •
Cited by 12 •
2015
Pulmonary vein isolation (PVI) with an ablation catheter is a curative treatment for atrial fibrillation (AF). Robotic catheter systems aim to improve catheter steerability. Here, a procedure with a new robotic catheter system is presented. The goal of the procedure is electrical block between pulmonary vein and left atrium.
04:42
Targeted Neuronal Ablation Using Two-Photon Microscopy in a Zebrafish Larava
0 Views •
2025
Source: Muto, A., et al. Ablation of a Neuronal Population Using a Two-photon Laser and Its Assessment Using Calcium Imaging and Behavioral Recording in Zebrafish Larvae. J. Vis. Exp. (2018) In this video, a two-photon laser ablation procedure is demonstrated, enabling the selective destruction of fluorescent neurons in agarose-immobilized zebrafish larvae. High-resolution imaging before and after the procedure confirms efficient neuronal damage, as observed by the absence of fluorescence.
FAQs
The lesion produced by alcohol ablation depends on more than ethanol concentration alone. Dose influences the extent of tissue injury, while the delivery route determines how ethanol reaches the target. Tissue anatomy also shapes spread and confinement, so clinicians must account for these variables when aiming for a therapeutic lesion that limits damage nearby.
Concentrated ethanol acts through several linked tissue effects. It disrupts cell membranes and proteins, causes local dehydration, and produces coagulative necrosis, meaning destruction of tissue with protein coagulation. These changes destroy or disable the targeted region rather than relying on a temporary functional effect, which helps explain its use against abnormal growth, obstruction, or electrical activity.
After ethanol reaches the target, vascular thrombosis may reduce local blood flow and contribute to the final lesion. Subsequent scar formation can consolidate the treated area and alter its structure or function. This sequence matters clinically because the desired result depends on creating a sufficiently localized injury, not simply introducing ethanol into tissue.
A typical treatment workflow places a needle or catheter at the selected target, delivers concentrated ethanol, and uses imaging and clinical monitoring to assess positioning and limit injury to nearby structures. The route is chosen according to the anatomy and condition being treated, while the delivered dose helps determine the resulting lesion.
Clinicians may consider alcohol ablation for hypertrophic obstructive cardiomyopathy, certain tumors, cysts, and pain-producing nerve pathways. The therapeutic goal differs by condition: reducing obstruction, destroying abnormal growth or cyst tissue, or disrupting a pathway associated with pain. These applications illustrate why target selection and anatomy must be matched to the clinical problem.
The procedure can reduce abnormal growth, obstruction, or electrical activity, depending on the target, and it may also address pain generated by selected nerve pathways. Its outcome is not uniform across conditions: lesion size and effect vary with dose, delivery route, and anatomy. Imaging and monitoring support evaluation of benefit while limiting injury to surrounding structures.