Thc

Tetrahydrocannabinol (THC) is the principal psychoactive cannabinoid in cannabis, a compound that matters in psychology because it can alter perception, mood, attention, memory, and motivation. THC primarily activates cannabinoid CB1 receptors in the brain, influencing endocannabinoid signaling and changing communication in neural circuits involved in reward, learning, stress, and sensory processing; effects depend on dose, individual biology, and context. Studying THC helps researchers investigate cognition, emotion, substance use, and vulnerability to adverse psychological outcomes, while also informing discussions of cannabis-related behavior, therapeutic development, and public health.

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JoVE Journal - Neuroscience
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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

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2025

Δ9-tetrahydrocannabinol (THC) is the intoxicating constituent in cannabis and a controlled substance in the United States. This article outlines standard procedures for obtaining, storing, and administering THC to mice complying with current legal regulations and briefly introduces a method to assess basic pharmacodynamic effects of THC in rodents.

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