7,205 Views
•
10:27 min
•
July 25, 2020
DOI:
Резюме
Automatically generated
Здесь мы представляем протокол для проверки эффективности целевых методов лечения, отобранных на основе геномного состава опухоли. Протокол описывает идентификацию и проверку структурных перестановок ДНК, привитие опухолей пациентов в мышей и тестирование ответов на соответствующие препараты.
Смотреть дополнительные видео
Видео по теме
09:29
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Видео по теме
13650 Views
09:53
Labeling of Breast Cancer Patient-derived Xenografts with Traceable Reporters for Tumor Growth and Metastasis Studies
Видео по теме
12102 Views
08:59
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
Видео по теме
7172 Views
04:49
Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research
Видео по теме
6303 Views
09:37
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Видео по теме
1745 Views
08:52
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
Видео по теме
3950 Views
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Видео по теме
6710 Views
06:08
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Видео по теме
1700 Views
07:10
Depletion of Mouse Cells from Human Tumor Xenografts Significantly Improves Downstream Analysis of Target Cells
Видео по теме
12613 Views
02:57
Targeted Cancer Therapies
Видео по теме
7529 Views
Read Article
Цитировать это СТАТЬЯ
Zhang, P., Kovtun, I. V. Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts. J. Vis. Exp. (161), e60646, doi:10.3791/60646 (2020).
Copy