Ion-Exchange Chromatography for Sample Cleanup

Ion-exchange chromatography is a separation method that cleans up samples by using charge. A column is packed with an ion-exchange resin, which is a charged stationary phase on a solid support. Strong cation-exchange chromatography uses a negatively charged resin to separate cations. Strong anion-exchange chromatography uses...

Ion-exchange chromatography is widely used in the separation and isolation of charged compounds, particularly large biomolecules.

This type of liquid chromatography uses a column of packed stationary-phase beads, called resin. The technique separates analytes based on their affinity with the charged resin.

There are two main types of...