Peptide Building on Solid Supports

Solid-phase synthesis builds a target compound while the starting molecule stays attached to a solid support. In Merrifield's method, the reactant molecule is bound to a resin and then carried through a series of chemical reactions. This Nobel Prize winning approach is especially useful for making compounds step by step.

Solid phase synthesis is a method in which the product is synthesized while bound to an insoluble material.

Solid phase synthesis is often used to produce biological oligomers and polymers such as peptides, nucleic acids, and oligosaccharides. These molecules are composed of chains of smaller molecular subunits, called monomers. Synthesiz...