NF-κB in Immune Defense and Disease

NF-κB is a transcription factor that helps control immune defense and inflammation in animals. It was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore because of its interaction with the immunoglobulin light chain enhancer in B-cells. Since then, researchers have shown that NF-κB regulates the expres...

NF-κB proteins are transcription factors that are involved in many crucial cellular functions such as immune cell activation, cell adhesion, antimicrobial response, and cell cycle regulation.

In the resting state, the NF-κB exists as a heterodimer directly bound to an inhibitory protein called IκBɑ. IκBɑ suppresses the activity of NF-κB a...