Chaperones Guide Protein Folding

Molecular chaperones help proteins fold into the correct shape. Protein folding is a key step after a protein is made, because shape affects function. If a protein does not fold properly, it may not work as it should.

Chaperones do not become part of the final protein. Instead, they assist the fo...

As they are synthesized in the cell, most proteins do not fold spontaneously into their native conformation but require a special class of proteins called chaperones to help fold them.

Of the several types of molecular chaperones found in prokaryotes and eukaryotes, the two major families are the heat shock proteins - hsp70 and hsp60.