Ig-CAMs in Neural Growth and Disease

Ig-CAMs, or immunoglobulin-like cell adhesion molecules, are cell surface glycoproteins in the immunoglobulin superfamily. They contain immunoglobulin domains, and some also have fibronectin type III domains. Their Ig domains can be glycosylated to different degrees. These molecules can bind to the same kind of Ig-CAM or to ...

Immunoglobulin-like cell adhesion molecules, or Ig-CAMs, have a characteristic immunoglobulin protein fold in their multiple extracellular binding domains, called Ig-domains.

These Ig-domains allow the Ig-CAMs to function diversely across different tissue types.

For instance, neural or NCAMs expressed on neurons bind to each other ...