Name: stroke volume: preload to afterload
Uploaded: 2025-05-15T09:18:04.000Z
Duration: 1 min 27 s
Channel: JoVE

K12 Standards

ohios-learning-standards-and-model-curriculum

Ohio’s Learning Standards and Model Curriculum

9-12

Human Anatomy and Physiology

Transport

Cardiovascular System

Regulation of Stroke Volume

The stroke volume, which is the volume of blood ejected by a ventricle with each heartbeat, is regulated by three factors: preload, contractility, and afterload. 
Preload is the degree of stretch in the cardiac muscles just before ventricular contraction. It is directly proportional to the end-diastolic volume.
According to the Frank-Starling law, greater preload means greater force of ventricular contraction and a higher stroke volume.
Certain factors, such as an increased ventricular filling during diastole, put more strain on the ventricular myocardium, increasing the preload and the stroke volume.
Contractility is the strength of contraction of ventricles at any given preload. Higher contractility pushes more blood out, reduces the end-systolic volume, and boosts the stroke volume.
Positive inotropic agents, like epinephrine, elevate contractility by enhancing calcium ion inflow into the muscle cells. Negative agents, like acetylcholine, reduce contractility by increasing potassium ion efflux from cardiac tissues.
Afterload refers to the threshold pressure needed for ventricular ejection. Higher afterload reduces ventricular pumping capacity. It increases the ESV and reduces str

regulation of stroke volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the heart, which states that the more the heart fills with blood during diastole (the relaxation phase), the greater the force of contraction during systole (the contraction phase). Preload is proportional to end-diastolic volume (EDV), the volume of blood in the ventricles at the end of diastole. Two factors determine EDV: the duration of ventricular diastole and venous return and the volume of blood returning to the right ventricle.
Contractility, the second factor, pertains to the strength of ventricular muscle fiber contraction at any given preload. Substances that increase contractility are called positive inotropic agents, and those that decrease it are negative inotropic agents. Positive inotropic agents often promote calcium inflow, strengthening the force of contraction. Factors like stimulation of the sympathetic division of the autonomic nervous system, hormones like epinephrine and norepinephrine, increased intracellular calcium levels, and certain drugs can have positive inotropic effects.
Afterload is the third factor and refers to the pressure that must be exceeded before the ejection of blood from the ventricles can occur. Increased afterload can cause stroke volume to decrease, leaving more blood in the ventricles after systole. Conditions like hypertension and atherosclerosis can increase afterload.

The stroke volume, which is the volume of blood ejected by a ventricle with each heartbeat, is regulated by three factors: preload, contractility, and ...

Education

JoVE Core

Anatomy and Physiology

Unit 1

The Heart

KEY TERMS AND CONCEPTS

stroke volume: preload to afterload

Stroke volume depends on preload, contractility, and afterload. These three factors work together to control how much blood a ventricle ejects with each heartbeat. Understanding them helps explain how the heart keeps blood moving through the circulatory system.

Preload is the stretch on the heart before it contracts. It is linked to the Frank-Starling law of the heart, which says that when the heart fills with more blood during diastole, it contracts more forcefully during systole. Preload is proportional to end-diastolic volume, or EDV, which is the amount of blood in the ventricles at the end of diastole.

Two things affect EDV. One is the length of ventricular diastole. The other is venous return, which is the amount of blood returning to the right ventricle.

Contractility is the strength of ventricular muscle fiber contraction at a given preload. Substances that raise contractility are called positive inotropic agents, while substances that lower it are negative inotropic agents. Positive inotropic effects often involve more calcium entering the cells, which helps the heart contract more strongly.

Several factors can increase contractility. These include stimulation of the sympathetic division of the autonomic nervous system, hormones such as epinephrine and norepinephrine, higher intracellular calcium levels, and some drugs. Afterload is the pressure the ventricle must overcome before blood can be ejected. When afterload increases, stroke volume can decrease, and more blood remains in the ventricles after systole. Hypertension and atherosclerosis can increase afterload.

Stroke Volume: Preload to Afterload

overview of the heart

How the Heart Pumps Blood

The heart is a muscular organ in the chest that pumps blood through the body. It works as the main pump of the vascular system. The heart has four chambers. The two atria are on top, and the two ventricles are below. Blood enters the right atrium from the body as deoxygenated blood, which means it has less oxygen. It then moves to the right ventricle. The right ventricle pumps this blood to the lungs for oxygenation. Oxygenated blood returns from the lungs to the left atrium. It then passes to...

location and orientation of the heart

Heart Position, Apex, and Pericardium

The human heart sits in the mediastinum, the middle space of the thorax. It is about the size of a fist and weighs about 250 to 350 grams. The heart lies on the superior surface of the diaphragm and extends obliquely for about 12 to 14 cm. The heart is positioned anterior to the vertebral column and posterior to the sternum. About two-thirds of its mass lies to the left of the midsternal line. The lungs lie on either side of the heart. The broad base of the heart points toward the right...

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Heart Wall Layers and Their Roles

The heart wall has three layers: the epicardium, myocardium, and endocardium. Each layer has a different structure and job. Together, they help the heart pump blood through the body. The outermost layer is the epicardium. It is the visceral layer of the serous pericardium. This layer has a thin, transparent mesothelial surface and an inner layer of areolar connective tissue. Fat deposits are also found here, and they increase with age. The myocardium is the thickest layer of the heart wall.

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The heart chambers work together to move blood through the body and the lungs. The human heart has four chambers: the right atrium, right ventricle, left atrium, and left ventricle. The atria are the upper chambers, and the ventricles are the lower chambers. They are separated by the interatrial septum and the interventricular septum. The outside of the heart also shows clear dividing lines. The coronary sulcus separates the atria from the ventricles. The anterior and posterior...

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The heart valves keep blood moving in one direction through the heart. The main valve groups are the atrioventricular, or AV, valves and the semilunar valves. Together, they help stop blood from flowing backward as the heart chambers contract and relax. The AV valves stop blood from moving back into the atria when the ventricles contract. They work with the chordae tendineae, which are tough cord-like strands, and the papillary muscles. When the ventricles relax, the chordae tendineae are...

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Pathway of Blood Through Heart and Lungs

The circulatory system moves blood in two linked routes: pulmonary circulation and systemic circulation. Together, these circuits carry blood between the heart, the lungs, and the rest of the body. Pulmonary circulation comes first in this cycle. In pulmonary circulation, deoxygenated blood is pumped from the right ventricle to the lungs through the pulmonary trunk and pulmonary arteries. In the lungs, the blood picks up oxygen. It then returns to the heart through the pulmonary veins and...

coronary circulation

How the Heart Gets Its Blood

Coronary circulation is the blood supply that keeps the heart muscle alive. The heart does not use the same blood it pumps to feed itself. Instead, it depends on a separate vessel network that delivers oxygen and nutrients to the myocardium, or heart muscle. This is the shortest circulation in the body. Coronary circulation begins at the base of the aorta, where the left and right coronary arteries arise. These arteries wrap around the heart in the coronary sulcus and send blood inward to the...

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The heart sets its own beat through autorhythmicity, which is its built-in ability to generate electrical signals and start muscle contractions. This process depends on a self-regulating conduction system. It includes pacemaker cells and specialized conducting cells. Pacemaker cells are found in two main nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node can depolarize on its own. That electrical change starts an action potential that causes the atria to contract. <br...

electrocardiogram

Reading Heart Waves on an ECG

An electrocardiogram, or ECG/EKG, records the heart’s electrical signals during each heartbeat. Electrodes are placed on the arms, legs, and chest. The electrocardiograph then amplifies the signals and creates 12 tracings that show the heart’s electrical activity from different views. A normal ECG has three main waveforms. The P wave shows atrial depolarization, which is the spread of action potentials through the atria. The QRS complex shows rapid ventricular depolarization, and the T wave...

cardiac cycle

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The heartbeat follows a set of stages that move blood through the heart. This process is driven by changes in pressure and by the opening and closing of the heart valves. It includes systole, or contraction, and diastole, or relaxation. The sequence starts in mid-to-late diastole, when the heart is fully relaxed. During this time, blood flows passively from the atria into the ventricles. Atrial systole then begins as the atria contract and push the remaining blood into the ventricles. Next...

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ECG Waves Across the Cardiac Cycle

ECG waves show how the heart’s electrical signals line up with the cardiac cycle. The electrical activity appears before the heart muscle’s mechanical contraction and relaxation. On an electrocardiogram, the main waves help link each electrical event to a specific stage of the heartbeat. A cardiac action potential starts in the SA node, or sinoatrial node, and spreads through the atria and the AV node in about 0.03 seconds. This creates the P wave on the ECG and triggers atrial contraction.

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Heart Rhythm Disorders and Emergency Care

Heart rhythm disorders, also called arrhythmias or dysrhythmias, happen when the heart’s conduction system has a defect. They can make the heart beat irregularly, too fast, or too slow. People may notice chest pain, shortness of breath, or fainting. Many things can trigger an arrhythmia. Stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte imbalances are all possible causes. These triggers can disrupt the electrical signals that control the...

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Auscultation is the process of listening to internal body sounds with a stethoscope. Heart sounds are created by turbulence in blood flow when the heart valves close. These sounds are usually heard best a little away from the valves, where the blood flow spreads the sound. The heart makes four types of sounds, but a stethoscope usually picks up only S1 and S2. S1 is the “lub” sound. It happens when the atrioventricular, or A-V, valves close at the start of ventricular systole. S1 is usually...

cardiac output and stroke volume

How Heart Rate Shapes Cardiac Output

Cardiac output shows how much blood the heart pumps each minute. It is the volume ejected by the left or right ventricle into the aorta or pulmonary trunk. Heart rate and stroke volume work together to set this value. Heart rate is the number of heartbeats per minute, and stroke volume is the amount of blood pumped out with each beat. Cardiac output is found by multiplying heart rate by stroke volume. In an average resting adult male, it is about 5.25 L/min. That estimate uses a heart rate of...

Stroke volume depends on preload, contractility, and afterload. These three factors work together to control how much blood a ventricle ejects with each heartbeat. Understanding them helps explain how the heart keeps blood moving through the circulatory system. Preload is the stretch on the heart before it contracts. It is linked to the Frank-Starling law of the heart, which says that when the heart fills with more blood during diastole, it contracts more forcefully during systole. Preload is...

regulation of heart rates

How the Heart Adjusts Its Beat

Heart rate changes through signals from the autonomic nervous system, hormones, and the heart's own built-in control systems. The autonomic nervous system has two main parts. The sympathetic nervous system raises heart rate, and the parasympathetic nervous system lowers it. The sympathetic nervous system releases norepinephrine and epinephrine. These chemicals act on beta-1 adrenergic receptors in the heart. They increase the rate of depolarization in the sinoatrial (SA) node, which is the...

exercise and cardiac output

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Exercise strengthens the heart and improves cardiovascular health. Aerobic exercise is especially effective. The American Heart Association recommends 150 minutes of moderate to intense aerobic exercise each week for a healthy heart. Brisk walking, running, bicycling, cross-country skiing, and swimming are all examples. These activities are best done three to five times per week. During sustained exercise, muscles need more oxygen. The body meets this demand through enough cardiac output and...

imbalances in cardiac output

Congestive Heart Failure Causes and Effects

Congestive heart failure (CHF) happens when the heart becomes an inefficient pump. The heart normally keeps blood leaving the heart and blood returning to it in balance. When that balance is disrupted, blood circulation drops and the body does not get enough flow. CHF can affect the left side of the heart, the right side, or both. Left-side failure can cause pulmonary congestion, which means blood backs up in the lungs. The right side may still send blood to the lungs, but the left side cannot...

development of the heart

Heart Tube Formation and Folding

Heart tube formation and folding shape the early human heart. The process begins in the mesoderm, a middle layer of embryonic tissue, on day 18 or 19 after fertilization. It starts in the cardiogenic area, a group of mesodermal cells at the head end of the embryo. These cells extend into cardiogenic cords and then change into hollow endocardial tubes. As the embryo folds from side to side, the paired tubes move closer together. They join into one primitive heart tube by day 21. By day 22, this...

key terms and concepts

Learn how preload, contractility, and afterload control stroke volume, including Frank-Starling law, venous return, calcium, and conditions that raise afterload.

Stroke Volume: Preload to Afterload | JoVE K12

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Stroke Volume: Preload to Afterload

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