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Chapter 10

Cell Cycle and Division

What is the Cell Cycle?
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two…
Genomic DNA in Prokaryotes
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the…
Binary Fission
Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in…
Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside…
Interphase
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of…
Mitosis and Cytokinesis
In eukaryotic cells, the cell's cycle—the division cycle—is divided into distinct, coordinated cellular processes that include cell…
Positive Regulator Molecules
The cell cycle is positively regulated—promoting progress through the stages—via the interaction of two classes of proteins found in the…
Negative Regulator Molecules
Several proteins negatively regulate the cell cycle to prevent replication from occurring before cells are ready. During G1, if a cell’s DNA is…
Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
Neurons of the cerebral cortex are generated during brain development from different types of neural stem and progenitor cells (NSPC), which form a…
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
This protocol describes a method to permit the tracking of cells through the cell cycle without requiring the cells to be synchronized. Achieving…
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
The gene expression program of the cell cycle represents a critical step for understanding cell cycle-dependent processes and their role in diseases…

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