One-Compartment Open Model for IV Bolus Administration: General Considerations

A one-compartment open pharmacokinetic model describes the drug concentration-time course in the body post-administration. It views the body as a single, homogenous compartment without barriers to drug movement.

The term 'open' signifies unidirectional drug input and output processes.

Drugs dynamically traverse this compartment, assuming rapid equilibrium between plasma and other body fluids. Here, the rate of absorption exceeds that of elimination.

Elimination follows a first-order process with a consistent rate constant. Furthermore, plasma is the reference compartment, with plasma drug concentration change proportional to tissue drug concentration changes.

This model is ideal for predicting the pharmacokinetics of rapidly dispersing drugs, like intravenous bolus-administered theophylline, for safe and effective dosing.

The rate of drug presentation to the body is defined by an equation representing the difference between the rate of drug entry and exit.

The pharmacokinetic parameters can be calculated directly from the plasma concentration-time profile or by using non-compartmental methods.