Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow

Summary

The topical anesthetic lidocaine was atomized using a high oxygen flow through the working channel of a flexible intubating endoscope to achieve topical airway anesthesia for awake endotracheal intubation. We prefer this modified spray-as-you-go technique for endoscopic intubation to classical bolus application because of higher patient satisfaction and better compliance.

Abstract

A patient's willingness to cooperate is an absolute precondition for successful awake intubation of the trachea. Whilst drug-sedation of patients can jeopardize their spontaneous breathing, topical anesthesia of the airway is a popular technique. The spray-as-you-go technique represents one of the simplest opportunities to anesthetize the airway mucosa. The application of local anesthetic through the working channel of the flexible endoscope is a widespread practice for anesthetists as well as pulmonologists. There is neither need for additional devices nor special training as a pre-requisite to perform this technique. However, a known clinical problem is the coughing and gagging reflex that may occur when the liquid anesthetic strikes the airway mucosa and other sensitive structures like the vocal cords. This can be avoided by the use of oxygen applied through the working channel with the aim of fogging the local anesthetic into finer particles. Furthermore, the oxygen flow provides a higher oxygen supply and contributes to a better view, dispersing mucus secretions and blood away from the lens. Using an atomizer with a high oxygen flow of 10 L/min we maximized these benefits, caused less coughing and had more satisfied and therefore cooperative patients. Possible, but very rare complications of using oxygen flow including gastric insufflation, organ rupture or barotrauma did not arise. We attribute the complication-free use of high oxygen flow to the design of the set, which permits flow and pressure release.

Introduction

Topical anesthesia of the airway for awake intubation is generally recommended to improve patient comfort, which will help make the procedure a success. The spray-as-you-go technique with high oxygen flow is a simple and safe concept that is finding a high level of acceptance among patients. The atomization of the local anesthetic by oxygen at a flow rate of 10 L/min results in less stimulation of the cough and gag reflex.

Faced with negative feedback from several patients, we decided to refine the standard institutional spray-as-you-go technique. This classical bolus application of local anesthetic consisted of two injections, each of 5 mL lidocaine 2% plus 5 mL air in a 10 mL syringe, first into the vocal cords and then, after a 2-min waiting time, into the trachea. Patients complained about the feeling of being drowned by the splash of the bolus striking their airway mucosa.

The spray-as-you-go technique is commonly used worldwide¹. This technique involves local anesthetic application through the working channel of a flexible intubating endoscope while advancing the tip through the upper and lower airway with the goal of intubating the patient´s trachea. There are multiple approaches in practice and several descriptions of methods in the literature. Initial experiences with the spray-as-you-go-technique in combination with application of a constant oxygen flow through the working channel were published in the 1990s². The focus here was on oxygen flow effects like cleaning the lens by dispersing mucus secretions and blood away from the lens and elevating the inspiratory oxygen delivery. The advantage of the oxygen flow in aiding atomization of local anesthetic was shown previously by Piepho and colleagues³. They described a vaporization technique, where the supply of 3 L/min oxygen resulted in less coughing by the patients. On the assumption that a flow of 10 L/min would atomize the local agent into finer particles that would evoke even less coughing, we successfully tested the atomizer at this higher flower rate. The atomizer consists of a small volume, kink-resistant, flexible, pressure-certified oxygen tube and a connecting tube. These are connected to a three-way sidearm fitting with a small flow-control opening.

The atomizer technique can be used for all airway situations. However, the device should be used cautiously distal from higher-grade airway stenosis caused by conditions such as tumor masses. The lack of backflow of oxygen could cause increased airway pressure and increases the risk of barotrauma. Also, the atomizer is a useful tool in an emergency setting. The preparation of the set needs less than a minute and the user needs no special training. In the following we present detailed operating instructions for the spray-as-you-go technique with high oxygen flow, illustrating the separate working steps.

Protocol

All procedures were approved by the ethics committee of the medical association of the State Rhineland-Palatinate and performed in accordance with the Declaration of Helsinki.

1. Atomizer⁴

1. Remove the set from package. Inspect the product to ensure there is no damage.
   NOTE: The device is intended for one-time use. Please refer to the instructions for use for further information about storage and supply (see Materials and Equipment Table).

2. General Preparation of the Patient

1. Administer premedication, e.g. Lorazepam 1 - 2.5 mg the evening before and/or 2 - 4 mg 1 - 2 h before the intervention (with attention to contraindications).
2. Establish monitoring parameters such as pulse oximetry (SpO₂), electrocardiography (ECG) and non-invasive blood pressure (NIBP).
   NOTE: Monitor patient sedation using standards such as Ramsay Sedation Scale and Bispectral Index monitoring. Close monitoring of the level of sedation can help prevent potential complications such as respiratory depression.
3. Secure a peripheral intravenous access.

3. Topical Anesthesia of the Upper Airway

1. Apply 1 mL mixture of lidocaine 2% with phenylephrine 0.25% to each nostril.
2. Apply lidocaine 10% spray twice directly onto the mucosa of the oropharynx, spraying from the tip to the back of the tongue. Ask the patient to gargle the lidocaine in the mouth for as long as possible.
   NOTE: Anesthesia of the supraglottic airway can be performed alternatively using cotton-tipped swabs or nasopharyngeal airways, drops, gel, swish and gargling, aspirating and spraying local anesthetics.

4. Analgo-sedation

1. Start analgo-sedation using i.v. medication, e.g. initial sufentanil bolus (< 60 kg: 5 µg; > 60 kg: 10 µg; > 100 kg: 15 µg).
   NOTE: Dose drug-induced sedation at the lowest level possible in order to prevent apnea or airway constriction.
2. Give an extra sufentanil i.v. bolus, e.g. 5 µg, as 'rescue' treatment until a Ramsay Sedation Score of 2 (cooperative, oriented, tranquil) is achieved.

5. Equipment Preparation

1. Assemble and check the flexible intubation endoscope according to institutional standards.
2. Connect the oxygen tube of the atomizer to the oxygen flow meter directly.
   Caution! Oxygen flow meters with humidifier bottles must not be used.
3. Attach the connecting tube to the Luer on the working channel of the endoscope. Set the oxygen flow rate to 10 L/min, as recommended in the instruction manual.
4. Connect a 1 mL syringe containing the lidocaine 2% solution to the three-way sidearm fitting.
   NOTE: Lidocaine 2% with its favorable efficacy profile is a suitable anesthetic.

6. Atomizer Technique

1. Close the flow-control opening using a finger. Rapidly inject the medication. Immediately release the flow-control opening.
   NOTE: A syringe must be connected to the three-way sidearm fitting to obtain a continuous low oxygen flow through the working channel.
2. While advancing the flexible endoscope in the airway, inject the local anesthetic using the atomizer at the following sites: inside nostril, on posterior nares; epiglottis; glottis; and vocal cords.
3. Repeat these steps as often as required while advancing the endoscope ("spray-as-you-go"). Before passing through the vocal cords, wait for 2 min to allow sufficient drug effect at the site.
   NOTE: Monitor sedation level of patient and top up sedation using i.v. medication (e.g. sufentanil 5 µg), as needed.

7. Flexible Endoscopic Intubation

1. Advance the endoscope carefully through the glottis into the trachea and position the tip of the endoscope just above the carina. Railroad a suitable sized, cuffed and lubricated flexible endotracheal tube over the endoscope into the trachea under rotation.
   NOTE: Avoid accidental advancement of the endoscope tip into a main stem bronchus.
2. Confirm placement of the endotracheal tube in the trachea just above the carina by visual control via the endoscope. Remove the endoscope, leaving the endotracheal tube in place.
3. Confirm the endotracheal position of the tube by measuring end tidal CO₂ using capnography in the spontaneously breathing patient.
4. Induce general anesthesia, e.g. intravenous Propofol 2 mg/kg/body weight. Start ventilating the patients according to current standards.

NOTE: The Enk Atomizer set is currently not available from Cook Medical.

Results

We performed awake flexible endoscopic intubation using the presented topical anesthesia technique in 48 patients. We succeeded in intubating all patients except one, who suffered from a stenosing tumor of the pharynx, which made it impossible to advance the tube.

The quality of awake intubation comfort was evaluated by patients, anesthetists and nurses using an 11-point visual analog scale (VAS) from 0 = not unpleasant to 10 = ...

Discussion

Here we demonstrate topical anesthesia using an atomizer with high oxygen flow for awake-endoscopic intubation. The first study to evaluate the atomizer technique compared it with classical boluses of topical anesthesia via the working channel of the flexible intubating endoscope⁵. Patients in the atomizer group evaluated their level of comfort as better than those in the control group and experienced fewer coughs and distinct coughing episodes. In addition, the atomizer technique was faster and less local ane...

Materials

List of materials used in this article

Name	Company	Catalog Number	Comments
Lidocaine 10% pump spray	e.g. AstraZeneca
Opiod for i.v. administration			Any opiod can be used. We prefer either Sufentanil or Fentanyl
Enk Fiberoptic Atomizer Set	Cook Medical	C-EFNS-100	The Enk Atomizer set is currently not available from Cook Medical
Lidocaine 2%	e.g. AstraZeneca
Intubation endoscope	e.g. Karl Storz Endoscope		We prefer a fibrescope with an outer diamter of 5 mm and a working channel with a diamter of 2 mm
Endotracheal tube	e.g. Rüsch		Size of the endotracheal tube needs to be adjusted to the patient. We prefer a ID 6.5 mm for nasal approach and ID 7.0 mm for oral approach
Anesthetic drug, e.g. Propofol 1%	e.g. AstraZeneca