$$\rightleftharpoonup{xx}$$
$$\longleftharp{xx}$$,
$$\longrightharp{xx}$$,
Functional restoration of the cerebral cortex relies on activity-dependent neuroplasticity following stroke. However, optimizing robotic rehabilitation for hand recovery remains a significant challenge. This proof-of-concept study investigates the feasibility of a configurable soft pneumatic robot in modulating the brain network among ten participants with hand motor impairments after stroke. The programmable robotic intervention was administered in a randomized sequence for resting-state assessment, slow-mode, and fast-mode robotic therapy by adjusting working mode, action time, and interaction duration. Functional near-infrared spectroscopy (fNIRS) was employed to measure cortical activity and functional connectivity. Additionally, graph theory metrics, including clustering coefficient, average path length, small-world index, global efficiency, degree centrality, and eigenvector centrality, were derived from fNIRS-based functional connectivity matrices. The results demonstrated that robotic intervention significantly improved clustering coefficient (P = 0.034), average path length (P = 0.007), and global efficiency (P = 0.001). While small-world index, degree centrality, and eigenvector centrality showed an increasing trend, these differences did not reach statistical significance. Moreover, fast-mode therapy induced more substantial changes in clustering coefficient compared to slow-mode therapy, suggesting a potentially stronger effect on neural reorganization. These findings preliminarily support the use of soft robotics with adjustable paradigms to enhance brain network connectivity and facilitate neuroplasticity following stroke. The observed improvements in global efficiency and small-world properties indicate that robotic therapy optimizes cortical organization, promoting functional recovery. Further studies with larger sample sizes and personalized intervention protocols are needed to confirm these results and explore their long-term effects.