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Implementing one-lung ventilation (OLV) in pediatric patients presents unique clinical challenges due to age-dependent physiological and anatomical constraints. As minimally invasive thoracic surgery expands in pediatrics, the demand for precise lung isolation has increased. This narrative review evaluates current techniques—single-lumen tubes (SLT), double-lumen tubes (DLT), and bronchial blockers (BB)—with a focus on their safety profiles and clinical indications. Findings indicate that DLTs remain the benchmark for older children but are anatomically prohibitive for those under 8–10 years or shorter than 130 cm. BBs are the primary alternative for children aged 2–8 years (ETT ID ≥4.5 mm), although traditional devices such as the Arndt-Fogarty blockers have design limitations. For infants under 2 years, the primary strategies remain SLT mainstem intubation or extraluminal blocker placement, both of which carry a risk of right upper lobe (RUL) obstruction. Emerging innovations, particularly 3D-printed anatomically customized blockers, are highlighted as potential solutions to resolve device “fit” challenges in infants. Perioperative management remains non-standardized; however, evidence-based recommendations emphasize lung-protective ventilation to reduce pulmonary complications. Hypoxemia occurs in approximately 26% of pediatric OLV cases and requires a prioritized management framework that includes fiberoptic verification, secretion clearance, and optimized PEEP/CPAP application. By synthesizing current evidence, this review provides a decision-making algorithm to guide optimal device selection and improve safety outcomes in this vulnerable pediatric population.