Using the hybrid robotic-assisted thoracic and transcervical approach, two patients with massive substernal goiters underwent successful en bloc resection without sternotomy or conversion to thoracotomy. In both cases, robotic mediastinal mobilization provided circumferential visualization of the substernal thyroid and surrounding neurovascular structures, facilitating subsequent transcervical delivery while avoiding excessive cervical traction. Estimated blood loss was limited to 50 mL and 100 mL, with operative times of 210 min and 298 min, respectively. No intraoperative or postoperative complications occurred. Both patients were started on a regular diet immediately after surgery, and had no reported changes in baseline voicing or acute dyspnea. PTH levels and calcium levels were normal. The second patient required supplemental oxygen via a 2 L nasal cannula for the first 24 h postoperatively. Exact pain scores and analgesic requirements were not collected. Chest drains were removed on post-operative day 1, and neck drains were removed on the second post-operative day. Both patients were discharged on postoperative day two. Both patients remain asymptomatic and disease-free at 12 and 18 months of follow-up, respectively.
Case 1 demonstrated the utility of this technique for a large posterior mediastinal goiter extending to the level of the carina. Preoperative computed tomography in Figure 2 illustrates the degree of posterior mediastinal extension, compression of the trachea and esophagus, and intimate relationship to the azygos vein, highlighting why a conventional transcervical approach would have required substantial blind inferior dissection or consideration of sternotomy.
During the robotic portion of the procedure, the mediastinal component was approached first. Figure 3 demonstrates the correct true capsular dissection plane along the thyroid capsule, separating from the azygos vein. Maintaining this avascular plane permitted progressive circumferential mobilization of the substernal component while minimizing manipulation of the adjacent mediastinal vessels. Continued dissection exposed the trachea, major vessels, esophagus, and right vagus nerve. Figure 4 demonstrates preservation of the vagus nerve after complete separation from the thyroid capsule, confirming adequate visualization of critical mediastinal neurovascular structures prior to cervical delivery. Once circumferential mobilization was completed, the remaining cervical attachments were released through the transcervical incision, allowing en bloc extraction without sternotomy. Figure 5 shows the intact specimen, whose final pathology demonstrated a 215 g multinodular goiter.
Case 2 illustrates the application of the technique in a technically challenging revision operation with dense cervical scarring and substernal extension below the aortic arch. Figure 6 shows pre-operative CT imaging demonstrating marked airway compression, extension into the anterior mediastinum, and compression of the innominate vein. Robotic dissection enabled direct visualization and preservation of the innominate vessels and right phrenic nerve, and the release of the mediastinal component from the anterior chest wall and internal mammary vessels before cervical dissection. Following complete mediastinal mobilization, the remaining thyroid was successfully delivered through the previous cervical incision despite significant pretracheal fibrosis. Final pathology demonstrated a 355 g multinodular goiter containing an incidental 0.6 cm papillary thyroid microcarcinoma without adverse pathological features. Surgical extent or adjuvant therapy was not adjusted.
These representative cases demonstrate several technical advantages of the hybrid approach. Robotic thoracic dissection provided enhanced visualization of mediastinal anatomy, enabling safe identification and preservation of major vascular structures and critical nerves, and establishing a circumferential capsular dissection plane prior to cervical mobilization. Complete mediastinal release reduced the need for blind traction through the thoracic inlet and enabled en bloc transcervical extraction without sternotomy in both patients. Although successful in these complex cases, the technique remains dependent on careful patient selection, multidisciplinary coordination, and experience with robotic mediastinal surgery. In patients with extensive vascular encasement, invasive malignancy, or inability to achieve a safe capsular dissection plane, conversion to sternotomy should remain a consideration.

Figure 1: Intraoperative port positioning and docking of the Da Vinci Xi robot. (A) Patient in left lateral decubitus positioning, with the camera in the 8th intercostal port position, and corresponding ports positioned adjacently. Note that a working port is being used in the 7th intercostal position, which is typically designated for the assistant port. (B) Schema of right lateral chest silhouette depicting typical placement with anatomic landmarks, angulation, and spacing to avoid external robotic arm collision. Please click here to view a larger version of this figure.

Figure 2: CT imaging demonstrating craniocaudal extension. (A) Mass effect on the laryngotracheal framework. (B) Posterior extension to the trachea abutting the esophagus (arrowhead). (C) Inferior extent at the carina abutting the azygous vein (arrow). Abbreviation: CT = computed tomography. Please click here to view a larger version of this figure.

Figure 3: Robotic view of the mediastinal dissection. The image shows the anatomic relationship of the mass (arrowhead) to the azygous vein (arrow), the subclavian vessels (bracket), and the undissected trachea anteriorly. The right upper lung lobe is gently retracted (bottom right). Please click here to view a larger version of this figure.

Figure 4: Preservation of the vagus nerve. Magnified robotic endoscopic view during the posterolateral dissection of the mass, mobilizing the lesion (retracted by the right-handed instrument) away from the vagus nerve (arrow). Please click here to view a larger version of this figure.

Figure 5: Resected hemithyroidectomy specimen. Hemithyroidectomy lesion excised en bloc, measuring roughly 16 cm in craniocaudal dimension and 215 g. Please click here to view a larger version of this figure.

Figure 6: CT imaging with anterior mediastinal extension. (A) The multilobulated mass extends into the retropharynx superiorly and the anterior mediastinum inferiorly. (B) Sagittal view highlighting inferior extension at the aortic arch, compressing the innominate vein (dashed circle). Abbreviation: CT = computed tomography. Please click here to view a larger version of this figure.