Current Methods in the Production and Evaluation of Radiotracers

TOPICAL COLLECTIONS

Guest Editor

Dr. Xiaoai Wu

Sichuan University, West China Hospital

Dr. Xiaoai Wu is currently working as an Assistant Professor in the Laboratory of Clinical Nuclear Medicine and a Director in the Chemistry division of the Nuclear Medicine Department at the West China Hospital, Sichuan University. His research interests are mainly focused on the development of novel radio-labeling strategies of positron emission radio-isotopes to biologically active molecules and the discovery of novel radio-pharmaceuticals for cancer and neurodegenerative diseases. He currently serves as a Principal Investigator or Co-investigator in more than 5 research projects funded by the Natural Science Foundation of China and the Department of Science and Technology of Sichuan. He has published more than 20 peer-reviewed articles in professional journals.

Collection Overview

Positron emission tomography (PET) is a nuclear medical technology that allows in vivo imaging and quantification of specific targets, as well as molecular and cellular processes in the living body. Radioactive tracers are crucial for PET and are composed of biologically active molecules (such as small molecular compounds, peptides, antibodies, and proteins) and positron emission radioactive nuclides. However, for most radioactive tracers, it is not easy to efficiently label radioactive nuclides to a specific compound efficiently in the beginning of the tracer development.

The study of radio-labelling reactions is key to promote the research and production of radiotracers, and to expand the scope of PET scans in clinical applications.

This Method Collections aims to bring together a wide range of techniques that have been developed for radiolabelling for small molecular compounds, peptides, antibodies, and proteins with 11C, 18F, 64Cu, 68Ga, 89Zr, etc. In addition, the in vitro and in vivo evaluations of the PET radiotracers are also important for their clinical translation.

Examples of methods to be included in this collection are: design and synthesis of intermediates for radio-labelling precursors; radio-labelling of 18F in the alkyl side chain of small molecules; radio-labelling of 18F in electron-deficient/donate aromatic ring of small molecules; radio-labelling of metal radio-nuclide with peptides, antibodies and proteins; LogP determination of radio-tracers; bio-distribution of radio-tracers; autoradiography of a radio-tracer (or additionally, in combination with immuno-histochemistry staining for the validation of specific targets); static/dynamic PET imaging and data reconstruction.

Articles

Determining Binding Affinity (K<sub>D</sub>) of Radiolabeled Antibodies to Immobilized Antigens

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Determining Binding Affinity (K_D) of Radiolabeled Antibodies to Immobilized Antigens

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2022

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Erika Belitzky¹, Alessandra Cavaliere¹, Khashayar Rajabimoghadam¹, Bernadette Marquez-Nostra¹

¹Department of Radiology and Biomedical Imaging, Yale University

Abstracts

Determination of the Radio-Chemical Purity of small molecular radiotracers

Fei Pan¹,

Lili Pan¹,

Xiaoai Wu^*1,

Songye Li^*2

¹Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China,

²PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA

Determination of the lipid-water partition coefficient of radiotracers

Fei Pan¹,

Jing Zhu²,

Lili Pan¹,

Songye Li^*3,

Xiaoai Wu^*1

²Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China; Respiratory and Critical Care Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, China; NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, China,

³PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA