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Lysophospholipid Effects on Organ Structure and Function

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Timothy Hla

Timothy Hla

Harvard Medical School, Boston Children’s Hospital

Timothy Hla received his PhD in biochemistry from The George Washington University. Following post-doctoral training with Tom Maciag, he started his laboratory at the Holland Laboratory at the American Red Cross, Rockville, MD. He was recruited to the University of Connecticut School of Medicine in Farmington, CT where he founded the research center for Vascular Biology and was eventually promoted to Professor. In 2009, he was recruited as a Professor and Director of the Center for Vascular Biology at Weill Cornell Medicine, Cornell University. He moved his research program to Boston Children's Hospital (BCH) in 2016 where he is appointed as an investigator at the Vascular Biology Program and Patricia K. Donohoe Professor of Surgery at the Harvard Medical School. Dr. Hla is currently heading a laboratory at the BCH to conduct basic research on lysophophospholipids in vascular, immune, and central nervous systems. Dr. Hla is an honorary member of the Japanese Biochemical Society, elected as a fellow of the American Association for Advancement of Science, received an honorary MD degree from the Goethe University, Frankfurt, Germany a MERIT award from the NHLBI, NIH in 2006. He currently holds the outstanding investigator award from the NHLBI, NIH.

Collection Overview

Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are produced by the metabolic breakdown of membrane phospholipids. In vertebrates, LPA and S1P act in the extracellular environment as agents of cell-cell communication and stimulate specific G protein-coupled receptors. This signaling system is extremely widespread and regulate embryonic development and normal physiological processes of almost all organ systems. In addition, dysregulation of LPA and S1P signaling systems contribute to many disease processes. Indeed, several lysophospholipid receptor modulators have been approved for use in the treatment of autoimmune diseases and several more are under clinical testing. The exponential growth of this field of research is due in part to seminal discoveries and technologies that enable basic research findings. This volume aims to feature critical research technologies in the lysophospholipid research field as well as emerging technologies to address important questions and future challenges.

Articles

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

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Cited by 3

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2022

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Abstracts

A stably established two-point injection lysophosphatidylcholine-induced focal demyelination model in mice

Daishi Tian*1

1Department of Neurology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology