Collection-image

TOPICAL COLLECTIONS

Visualizing Intracellular Organelles 

Submit Abstract

Guest Editor

Su Guo

Su Guo

University of California, San Francisco

Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. After graduation, she became fascinated with how the brain works. As a research and postdoctoral fellow at Harvard Medical School and Genentech Inc. respectively, she carried out neurobiological studies of the development of brain neurotransmitter systems, using the vertebrate genetic model organism zebrafish. After establishing her independent research lab at the University of California, San Francisco, Dr. Guo has continued to study the molecular genetics of neural development and has expanded her research into the understanding of behaviour. With her research, Dr. Guo strives to make significant contributions to our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.

Collection Overview

Cells are fundamental units of multi-cellular organisms. Inside each cell, small structures called organelles perform vital roles that support the function of cells, and in turn, the organisms. To understand their intricate functions, it is important to be able to visualize their dynamics or structures at high resolution. Organelles of interest include endosomes, mitochondria, endoplasmic reticulum, nucleus, Golgi, and lysosomes, to name a few. Also, viral particles are sometimes “unwanted” organelles that hijack cellular machinery. Visualization in intact organisms or cultured cells can be included in this collection. The aim of this collection is to include visualization protocols of the following interest: 1) how to label the organelles of interest? 2) How to track their dynamics in vivo or in cultured cells? 3) How to visualize them at super-resolution?

Articles

Label-Retention Expansion Microscopy (LR-ExM) Enables Super-Resolution Imaging and High-Efficiency Labeling
7:44

Label-Retention Expansion Microscopy (LR-ExM) Enables Super-Resolution Imaging and High-Efficiency Labeling

0 Views

•

Cited by 8

•

2022

•

Abstracts

Methods for Visualizing Intracellular Organelles

Xiang Zhao*1

1University of California San Francisco, San Francisco, United States