Guest Editors
Néstor J. Martínez-Hernández
University Hospital La Ribera, Alzira, València, Spain
Néstor J. Martínez-Hernández is a thoracic surgeon who was born in Valencia, Spain, and attended to Valencia University, School of Medicine. He specialized in thoracic surgery in Valencia University General Hospital, after wards he moved to University Hospital of la Ribera, in Alzira. He received his PhD from Valencia University. His thesis work, in the group of Dr. Manuel Mata-Roig, focused on the development of an experimental transplantation of decellularized tracheas protocol in rabbit model. He has also developed and published several papers on clinical tracheal surgery in human, being also the editor of the Spanish Society of Thoracic Surgery Consensus Document on airway surgery in 2015. He is nowadays Coordinator of the Scientific Committee of the Spanish Society of Thoracic Surgery and the thoracic surgery editor of “Cirugía Española”, the official Spanish surgery journal.
Manuel Mata-Roig
Department of Pathology, Medicine and Odontology Faculty, Universitat de València, València, Spain
Manuel finished his degree in Biology in 1997 (University of Alicante, Spain) after which he received a research fellowship from the European Union in the laboratory of Professor Francisco Rodriguez Valera (Microbiology Department, UMH, Alicante, Spain). In 2000, Manuel received a research pre-doctoral fellowship (Ministry of Science, Spanish government) in the laboratory of Professor Julio Cortijo Gimeno (Pharmacology Department, University of Valencia, Spain). He defended his pre-doctoral thesis in December 2003 reaching the grade of “sobresaliente” cum laude. He got a PhD position in the Unidad Central de Investigación (University of Valencia, Spain) from 2004-2008 and in 2008, he got associated researcher position at the Research Foundation of the University General Hospital of Valencia (Spain) where he first worked as laboratory manager, and later as head of the Office of Research Management. In 2013, he got promoted as Professor in the Pathology Department of the University of Valencia (Spain). His ORCID ID is 0000-0002-1506-7983.
Collection Overview
Diseases of the respiratory system, an essential element for life, are among the ten main causes of death worldwide. These conditions have been extensively studied. However, many of these diseases are incurable unless the affected organ can be replaced through transplantation.
Despite the long history of lung transplantation, many aspects are not well-understood, with a wide margin for improvement, but this will require extensive research. In this regard, new strategies and experimental models are needed to better understand both whole organ transplantation and cell-based transplantation in diseases such as lung cancer.
In cases with chest wall involvement, the wall can be reconstructed through a prosthesis, flap, or graft. However, there is still a lack of standard protocols for other components of the respiratory system such as the airway, and the optimal approach—whether total or partial replacement—remains unclear. There is currently an area of intense research, although experience in humans is still limited.
In this context, this collection of articles aims to report relevant advances in the field of lung and airway transplantation, including clinical developments and novel strategies based on the use of in vitro and in vivo experimental models.
Articles
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Cited by 6
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2022
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Sara Naranjo Gozalo1,2, Maria de los Angeles Ballesteros Sanz3, Carlos Alvarez De Arriba1, Victor Manuel Mora Cuesta4, Eduardo Miñambres García2,3, Laura Sánchez Moreno1
1Department of Thoracic Surgery and Lung transplant Unit, University Hospital Marqués de Valdecilla, 2University of Cantabria School of Medicine, 3Intensive Care Unit, Donor Coordination Unit, University Hospital Marqués de Valdecilla, 4Department of Pneumology, Lung Transplant Unit, University Hospital Marqués de Valdecilla
Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
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Cited by 1
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2023
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Néstor J. Martínez-Hernández1, Lara Milián-Medina2, Jorge Mas-Estellés3, José L. Monroy-Antón4, José L. López-Villalobos5, David Hervás-Marín6, Amparo Roig-Bataller1, Manuel Mata-Roig2,7,8
1Thoracic Surgery Department, Hospital Universitari de la Ribera, 2Pathology Department, Universitat de Valencia Facultat de Medicina i Odontologia, 3Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 4Radiation Oncology, Hospital Universitari de la Ribera, 5Thoracic Surgery Department, Hospitales Universitarios Virgen del Rocío, 6Department of Applied Statistics and Operations Research and Quality, Universitat Politècnica de València, 7Networking Research Center on Respiratory Diseases (CIBERER), 8INCLIVA Biomedical Research Institute
Abstracts
Bioluminiscent mouse orthotopic lung cancer model for testig targeted therapies
Julian Carretero*1
1University of Valencia
Outcomes of lung transplantation after exvivo lung perfusion with Scandinavian protocol: Single-center experience Spain.
Lucas Hoyos *1
1Hospital Universitario Puerta de Hierro Majadahonda
Soluble form of the receptor for advanced glycation end products (sRAGE): is it a predictor of primary graft dysfunction after lung transplantation?
Silvana Crowley Carrasco*1
1University Hospital Puerta de Hierro-Majadahonda, Madrid
LUNG PROCUREMENT IN CONTROLLED NON HEART BEATING DONORS: COMBINED LUNG COOLING RAPID RECOVERY EXTRACTION AND ABDOMINAL GRAFTS PROCUREMENT USING ABDOMINAL NORMOTERMIC REGIONAL PERFUSION: HOW WE DO IT.
Roberto Mons1,
Victor Mora 2,
Sara Naranjo *3,
Laura Sánchez4,
Carlos Alvarez 4,
Eduardo Miñambres5,
Maria Angeles Ballesteros6
1Chieff of the thoracic surgery service and Lung Transplant Surgical Coordinator at University Hospital Marqués de Valdecilla-IDIVAL, Santander , Spain,
2Pneumologist and Lung Transplant Medical Coordinator at University Hospital Marqués de Valdecilla-IDIVAL, Santander , Spain,
3General thoracic surgeon and Lung Transplant Unit at University Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander , Spain,
4General thoracic and Lung Transplant Unit surgeon at University Hospital Marqués de Valdecilla-IDIVAL, Santander , Spain,
5Transplant coordination Unit and Service of Intensive care at University Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander , Spain,
6Transplant coordination Unit and Service of Intensive care at University Hospital Marqués de Valdecilla-IDIVAL, Santander , Spain
Functional and structural characterisation of respiratory mucosa
Ana Reula*1,
Lara Milian2,
Manuel Mata3,
Carmen Carda3,
Rosana Blanco4,
Javier Zurriaga3,
Miguel Armengot5,
María Sancho-Tello3,
Noelia Muñoz-Fernández6
1Department of Biomedical Sciences. Cardenal Herrera-CEU University. Castellón, Spain.,
2Department of Pathology. University of Valencia. Valencia, Spain.,
3Department of Pathology. University of Valencia. Valencia, Spain,
4Pathological Anatomy Service. La Fe University and Polytechnic Hospital.,
5Department of Surgery. University of Valencia. Valencia, Spain.,
6ENT Department. La Fe. La Fe University and Polytechnic Hospital.
Standardization of a Protocol for the Decellularization and Cryopreservation of Porcine Tracheal Rings.
Lara Milian1,
Manuel Mata*1,
Carmen Carda1,
Irene Monleon1,
Zakaria Oguir1,
Javier Zurriaga2,
Maria Sancho-Tello1,
Jose Javier Martin de Llano1,
Néstor Martinez-Hernández3
1University of Valencia,
2IMED,
3La Ribera Hospital
Lung Transplantation Surgical Technique
Norberto Santana Rodriguez*1
1Thoracic Surgery & Lung Transplant. Lung Health Centre. Organ Transplant Centre of Excellence. King Faisal Specialist Hospital & Research Centre