Guest Editors
Deokho Lee
Laboratory of Photobiology, Keio University School of Medicine & Keio University School of Medicine, Department of Ophthalmology
Deokho Lee received a Bachelor's of Science in Biotechnology in College of Life Science at CHA University, South Korea in 2015. He earned his Master's of Science in the Department of Brain and Cognitive Sciences at Daegu Gyeongbuk Institute of Science and Technology (DGIST), South Korea in 2017. He worked in R&D Center ViroMed Co., Ltd. as a research scientist in peripheral neuropathy, until 2018, then he moved to the Institute of Endemic Diseases Medical Research Center at Seoul National University College of Medicine as a research assistant/lab manager in ophthalmology and parasitology, South Korea, up through 2020. Also, he participated in the Health Promoting Schools project and the Dr. LJW Fellowship program in Fiji and/or Lao PDR. He is currently a PhD student/research assistant in the Laboratory of Photobiology in Department of Ophthalmology at Keio University Graduate School of Medicine, Japan. Deokho Lee focuses on how hypoxia/ischemia affects visual function using in vitro and in vivo experimental models, and studies developing various therapeutic approaches against vision loss, including hypoxia-inducible factor (HIF) inhibition and peroxisome proliferator-activated receptor alpha (PPARα) activation.
Toshihide Kurihara
Keio University School of Medicine, Laboratory of Photobiology & Keio University School of Medicine, Department of Ophthalmology
Dr. Toshihide Kurihara received his MD from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his PhD degree from Keio University Graduate School of Medicine, Tokyo, Japan in 2009. Then, he worked as a Research Associate at the Scripps Research Institute (TSRI) in La Jolla, California, USA, until 2013. Dr. Kurihara is currently an Assistant Professor of Ophthalmology at Keio University, and a Principal Investigator in Laboratory of Photobiology at Keio University, Japan. He serves as an Editorial Board Member in Frontiers in Neuroscience, Frontiers in Immunology, Frontiers in Ophthalmology, BioMed, International Journal of Molecular Sciences, BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine. Dr. Kurihara is interested in hypoxia responses in the development, physiology and pathophysiology of the retina, therapeutic visual restoration utilizing optogenetics, and myopia progress control by light environments.
Collection Overview
Ocular ischemia occurs when the ocular blood supply is insufficient, which induces metabolic dysregulation due to the lack of oxygen. These alterations can cause irreversible cell death in the eye, eventually resulting in vision impairment. Ocular ischemia is seen in many ocular diseases and disorders, including age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, cataract, corneal blindness, or occlusion(s) of ocular vasculatures, mediated by systemic metabolic disorders. To understand a series of ocular injury events evoked by ocular ischemia and ultimately develop effective treatments for the diseases, in vivo, ex vivo, and in vitro study methods for ocular ischemia and vision loss are needed.
The objectives of this methods collection are (1) to highlight the importance of researching various ocular ischemic diseases such as AMD, DR, glaucoma, cataracts, corneal blindness, or occlusion(s) of ocular vessels mediated by systemic metabolic disorders; (2) to share the step-by-step and in vivo, ex vivo, and in vitro methods that are being used; and (3) to encourage new cross-disciplinary idea formulation. We welcome a wide range of manuscripts on current and new in vivo, ex vivo, and in vitro methods of assessing, developing, attenuating, or preventing ocular ischemic injury with vision loss to be useful for interested scientists in this clinically relevant area of research.
