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Emerging Techniques in Cancer Neuroscience

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Jeremy Borniger

Jeremy Borniger

Cold Spring Harbor Laboratory

Dr. Borniger is an assistant professor at Cold Spring Harbor Laboratory in New York. Born in Washington, D.C., he received his B.A. in biological anthropology from Indiana University – Bloomington and then his PhD in neuroscience from The Ohio State University. He then completed a BRAIN Initiative postdoctoral fellowship at Stanford University before starting his faculty position in early 2020. His group is focused on unraveling the complex interactions between the nervous system and cancer in the body. To accomplish this, his lab uses techniques from systems neuroscience, immunology, and molecular biology to interrogate neuronal-cancer interactions at multiple spatiotemporal scales. In his dissertation work, Dr. Borniger demonstrated that non-metastatic breast cancer could distally alter the activity of neurons in the hypothalamus controlling arousal and systemic energy balance. Blockade of this aberrant neuronal activity was sufficient to improve sleep and rescue systemic changes in metabolism. These findings provided a potential mechanism driving cancer-associated sleep disruption, which is a common complaint of patients with breast cancer. In his spare time, Dr. Borniger likes to play piano and scuba dive when he gets the chance.

Collection Overview

Recent work has cemented the idea that the nervous system plays an active and important role in the initiation, proliferation, metastatic spread, and therapeutic resistance of diverse cancers. A major hurdle to future discoveries in this domain is the limited interaction among cancer biologists, neuroscientists, and clinicians. This prevents targeted methods from being developed and promotes the ‘re-purposing’ of existing approaches to answer questions in cancer neuroscience. The proposed collection will address this by focusing on new and emerging techniques at the nexus of neuroscience and cancer research, with the ultimate goal of serving as a resource for new and established investigators to make discoveries in this exciting field.

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Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
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Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

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Cited by 3

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2022

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