Guest Editors
John Yoon
University of California Davis School of Medicine, Department of Internal Medicine
Dr. John Yoon's laboratory is interested in the control of energy balance and thermogenesis and how it relates to human diseases. Ongoing work utilizes a combination of experimental approaches to investigate the roles of several proteins the lab has identified as controlling energy balance. A long-term goal is to find therapeutic agents for human disorders associated with abnormally regulated energy balance. A related area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease.
Maria Chondronikola
University of California Davis, Department of Nutrition and University of California Davis School of Medicine, Department of Radiology
Dr. Maria Chondronikola is a clinical and translational investigator in area of human nutrition and metabolism. Her research involves the use of both basic and clinical research tools to evaluate cellular, tissue-specific, and whole-body substrate metabolism to test physiologically important and clinically relevant hypotheses in human subjects in vivo. Her laboratory is currently focused on understanding the role of the brown adipose tissue in health and disease and the effect of targeted meal timing in metabolic function in populations at high risk for the development of metabolic disease.
Collection Overview
Adipocyte thermogenesis has emerged as a potential target to produce metabolic benefits. We will cover some of the experimental methods commonly used in studying thermogenesis in cellular models, mouse models, and humans. This can include seahorse respirometry with cultured adipocytes, oroboros high-resolution respirometry with freshly isolated adipose tissue samples, acute cold challenge study, imaging methods for the assessment of BAT volume and activity (PET, MRI, and others), sampling of the human BAT, indirect calorimetry with or without adrenergic stimulation, methods for the assessment of browning of white adipose tissue and In vitro models of human BAT.
Articles
